Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4561604..4562101 Replicon chromosome
Accession NZ_CP122676
Organism Escherichia coli strain ETEC4070

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDW57_RS22480 Protein ID WP_001173343.1
Coordinates 4561604..4561777 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDW57_RS22485 Protein ID WP_000398619.1
Coordinates 4561805..4562101 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW57_RS22470 (4558274) 4558274..4559731 + 1458 WP_001550473.1 dipeptide/tripeptide permease DtpC -
QDW57_RS22475 (4559968) 4559968..4561485 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDW57_RS22480 (4561604) 4561604..4561777 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDW57_RS22485 (4561805) 4561805..4562101 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDW57_RS22490 (4562329) 4562329..4562601 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QDW57_RS22495 (4562613) 4562613..4562843 - 231 WP_001550470.1 4Fe-4S mono-cluster protein YjdI -
QDW57_RS22500 (4563023) 4563023..4564654 + 1632 WP_001216482.1 sensor histidine kinase -
QDW57_RS22505 (4564651) 4564651..4565370 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4522835..4562101 39266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T277646 WP_001173343.1 NZ_CP122676:c4561777-4561604 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277646 WP_000398619.1 NZ_CP122676:c4562101-4561805 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References