Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4549545..4550380 | Replicon | chromosome |
| Accession | NZ_CP122676 | ||
| Organism | Escherichia coli strain ETEC4070 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A3A6S2N5 |
| Locus tag | QDW57_RS22435 | Protein ID | WP_000854800.1 |
| Coordinates | 4550003..4550380 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A3Z2YIX3 |
| Locus tag | QDW57_RS22430 | Protein ID | WP_032178229.1 |
| Coordinates | 4549545..4549913 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QDW57_RS22405 (4546656) | 4546656..4547474 | + | 819 | WP_001234392.1 | DUF932 domain-containing protein | - |
| QDW57_RS22410 (4547566) | 4547566..4548051 | + | 486 | WP_000213706.1 | antirestriction protein | - |
| QDW57_RS22415 (4548066) | 4548066..4548542 | + | 477 | WP_001186784.1 | RadC family protein | - |
| QDW57_RS22420 (4548611) | 4548611..4548832 | + | 222 | WP_000692353.1 | DUF987 domain-containing protein | - |
| QDW57_RS22425 (4548851) | 4548851..4549495 | + | 645 | WP_000086748.1 | hypothetical protein | - |
| QDW57_RS22430 (4549545) | 4549545..4549913 | + | 369 | WP_032178229.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| QDW57_RS22435 (4550003) | 4550003..4550380 | + | 378 | WP_000854800.1 | TA system toxin CbtA family protein | Toxin |
| QDW57_RS22440 (4550377) | 4550377..4550865 | + | 489 | WP_000779171.1 | DUF5983 family protein | - |
| QDW57_RS22445 (4550877) | 4550877..4551074 | + | 198 | WP_001374283.1 | DUF957 domain-containing protein | - |
| QDW57_RS22450 (4551159) | 4551159..4552001 | + | 843 | WP_063086391.1 | DUF4942 domain-containing protein | - |
| QDW57_RS22455 (4552750) | 4552750..4554288 | + | 1539 | WP_001187196.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4522835..4562101 | 39266 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14068.13 Da Isoelectric Point: 9.1376
>T277645 WP_000854800.1 NZ_CP122676:4550003-4550380 [Escherichia coli]
MKTLPVLPGQAAGLRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDKPGF
NACTHSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHSEAKR
MKTLPVLPGQAAGLRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDKPGF
NACTHSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHSEAKR
Download Length: 378 bp
Antitoxin
Download Length: 123 a.a. Molecular weight: 13823.58 Da Isoelectric Point: 6.3177
>AT277645 WP_032178229.1 NZ_CP122676:4549545-4549913 [Escherichia coli]
VSDTLHETNYPDDNNDRSWWGLPCTVTPCFRARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLHETNYPDDNNDRSWWGLPCTVTPCFRARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3A6S2N5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3Z2YIX3 |