Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3780057..3780675 Replicon chromosome
Accession NZ_CP122676
Organism Escherichia coli strain ETEC4070

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDW57_RS18675 Protein ID WP_001291435.1
Coordinates 3780457..3780675 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDW57_RS18670 Protein ID WP_000344800.1
Coordinates 3780057..3780431 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW57_RS18660 (3775146) 3775146..3776339 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDW57_RS18665 (3776362) 3776362..3779511 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
QDW57_RS18670 (3780057) 3780057..3780431 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDW57_RS18675 (3780457) 3780457..3780675 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDW57_RS18680 (3780847) 3780847..3781398 + 552 WP_063118620.1 maltose O-acetyltransferase -
QDW57_RS18685 (3781514) 3781514..3781984 + 471 WP_063085325.1 YlaC family protein -
QDW57_RS18690 (3782148) 3782148..3783698 + 1551 WP_063085326.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDW57_RS18695 (3783740) 3783740..3784093 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDW57_RS18705 (3784472) 3784472..3784783 + 312 WP_000409911.1 MGMT family protein -
QDW57_RS18710 (3784814) 3784814..3785386 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277641 WP_001291435.1 NZ_CP122676:3780457-3780675 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277641 WP_000344800.1 NZ_CP122676:3780057-3780431 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References