Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3348046..3348751 Replicon chromosome
Accession NZ_CP122676
Organism Escherichia coli strain ETEC4070

Toxin (Protein)


Gene name relE Uniprot ID A0A3A6SJV3
Locus tag QDW57_RS16660 Protein ID WP_063085620.1
Coordinates 3348046..3348432 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QDW57_RS16665 Protein ID WP_001280945.1
Coordinates 3348422..3348751 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW57_RS16640 (3344050) 3344050..3344676 + 627 WP_001314584.1 glutathione S-transferase GstB -
QDW57_RS16645 (3344673) 3344673..3345788 - 1116 WP_063085618.1 aldose sugar dehydrogenase YliI -
QDW57_RS16650 (3345899) 3345899..3346282 - 384 WP_000497137.1 biofilm formation regulator BssR -
QDW57_RS16655 (3346495) 3346495..3347820 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
QDW57_RS16660 (3348046) 3348046..3348432 + 387 WP_063085620.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDW57_RS16665 (3348422) 3348422..3348751 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
QDW57_RS16670 (3348821) 3348821..3350149 - 1329 WP_000086873.1 GGDEF domain-containing protein -
QDW57_RS16675 (3350157) 3350157..3352505 - 2349 WP_021523051.1 EAL domain-containing protein -
QDW57_RS16680 (3352683) 3352683..3353594 - 912 WP_001236019.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14280.45 Da        Isoelectric Point: 9.9296

>T277640 WP_063085620.1 NZ_CP122676:3348046-3348432 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSTKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT277640 WP_001280945.1 NZ_CP122676:3348422-3348751 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6SJV3

Antitoxin

Source ID Structure

References