Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2617081..2617719 Replicon chromosome
Accession NZ_CP122676
Organism Escherichia coli strain ETEC4070

Toxin (Protein)


Gene name hicA Uniprot ID A0A3A6S5Q3
Locus tag QDW57_RS12895 Protein ID WP_063085535.1
Coordinates 2617543..2617719 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDW57_RS12890 Protein ID WP_001270286.1
Coordinates 2617081..2617497 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW57_RS12865 (2612129) 2612129..2612248 - 120 Protein_2518 ABC transporter permease -
QDW57_RS12870 (2612221) 2612221..2613174 - 954 WP_242378934.1 ABC transporter permease -
QDW57_RS12875 (2613175) 2613175..2614188 - 1014 WP_063085537.1 ABC transporter ATP-binding protein -
QDW57_RS12880 (2614206) 2614206..2615351 - 1146 WP_000047450.1 ABC transporter substrate-binding protein -
QDW57_RS12885 (2615596) 2615596..2617002 - 1407 WP_063085536.1 PLP-dependent aminotransferase family protein -
QDW57_RS12890 (2617081) 2617081..2617497 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDW57_RS12895 (2617543) 2617543..2617719 - 177 WP_063085535.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDW57_RS12900 (2617941) 2617941..2618171 + 231 WP_000494244.1 YncJ family protein -
QDW57_RS12905 (2618263) 2618263..2620224 - 1962 WP_063085534.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDW57_RS12910 (2620297) 2620297..2620833 - 537 WP_000429507.1 DNA-binding transcriptional regulator SutR -
QDW57_RS12915 (2620925) 2620925..2622096 + 1172 Protein_2528 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.78 Da        Isoelectric Point: 11.5666

>T277638 WP_063085535.1 NZ_CP122676:c2617719-2617543 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPNDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277638 WP_001270286.1 NZ_CP122676:c2617497-2617081 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6S5Q3

Antitoxin

Source ID Structure

References