Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2529440..2531028 Replicon chromosome
Accession NZ_CP122676
Organism Escherichia coli strain ETEC4070

Toxin (Protein)


Gene name hipA Uniprot ID A0A3A6RNL0
Locus tag QDW57_RS12500 Protein ID WP_063085289.1
Coordinates 2529706..2531028 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QDW57_RS12495 Protein ID WP_001296726.1
Coordinates 2529440..2529706 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW57_RS12495 (2529440) 2529440..2529706 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QDW57_RS12500 (2529706) 2529706..2531028 + 1323 WP_063085289.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QDW57_RS12505 (2531426) 2531426..2532323 - 898 Protein_2446 LysR substrate-binding domain-containing protein -
QDW57_RS12510 (2532463) 2532463..2532771 + 309 WP_001221046.1 hypothetical protein -
QDW57_RS12515 (2532780) 2532780..2533469 + 690 WP_000801314.1 type 1 glutamine amidotransferase domain-containing protein -
QDW57_RS12520 (2533531) 2533531..2534478 + 948 WP_063085290.1 aldo/keto reductase -
QDW57_RS12525 (2534581) 2534581..2534736 + 156 WP_001327998.1 hypothetical protein -
QDW57_RS12530 (2534696) 2534696..2535115 + 420 WP_001314733.1 amidohydrolase family protein -
QDW57_RS12535 (2535105) 2535105..2535257 + 153 WP_001314732.1 amidohydrolase family protein -
QDW57_RS12540 (2535407) 2535407..2535979 + 573 WP_000789914.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49313.91 Da        Isoelectric Point: 8.5849

>T277637 WP_063085289.1 NZ_CP122676:2529706-2531028 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDHVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT277637 WP_001296726.1 NZ_CP122676:2529440-2529706 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6RNL0

Antitoxin

Source ID Structure

References