Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 911418..912072 Replicon chromosome
Accession NZ_CP122676
Organism Escherichia coli strain ETEC4070

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QDW57_RS04395 Protein ID WP_000244781.1
Coordinates 911665..912072 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QDW57_RS04390 Protein ID WP_000354046.1
Coordinates 911418..911684 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW57_RS04370 (907506) 907506..908939 - 1434 WP_063085817.1 6-phospho-beta-glucosidase BglA -
QDW57_RS04375 (908984) 908984..909295 + 312 WP_001182952.1 N(4)-acetylcytidine aminohydrolase -
QDW57_RS04380 (909459) 909459..910118 + 660 WP_000250269.1 hemolysin III family protein -
QDW57_RS04385 (910195) 910195..911175 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
QDW57_RS04390 (911418) 911418..911684 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QDW57_RS04395 (911665) 911665..912072 + 408 WP_000244781.1 protein YgfX Toxin
QDW57_RS04400 (912112) 912112..912633 - 522 WP_001055888.1 flavodoxin FldB -
QDW57_RS04405 (912745) 912745..913641 + 897 WP_000806652.1 site-specific tyrosine recombinase XerD -
QDW57_RS04410 (913666) 913666..914376 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDW57_RS04415 (914382) 914382..916115 + 1734 WP_000813177.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T277629 WP_000244781.1 NZ_CP122676:911665-912072 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT277629 WP_000354046.1 NZ_CP122676:911418-911684 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References