Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2617083..2617721 Replicon chromosome
Accession NZ_CP122673
Organism Escherichia coli strain ETEC4071

Toxin (Protein)


Gene name hicA Uniprot ID A0A3A6S5Q3
Locus tag QDW56_RS12895 Protein ID WP_063085535.1
Coordinates 2617545..2617721 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDW56_RS12890 Protein ID WP_001270286.1
Coordinates 2617083..2617499 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW56_RS12865 (2612131) 2612131..2612250 - 120 Protein_2518 ABC transporter permease -
QDW56_RS12870 (2612223) 2612223..2613176 - 954 WP_242378934.1 ABC transporter permease -
QDW56_RS12875 (2613177) 2613177..2614190 - 1014 WP_063085537.1 ABC transporter ATP-binding protein -
QDW56_RS12880 (2614208) 2614208..2615353 - 1146 WP_000047450.1 ABC transporter substrate-binding protein -
QDW56_RS12885 (2615598) 2615598..2617004 - 1407 WP_063085536.1 PLP-dependent aminotransferase family protein -
QDW56_RS12890 (2617083) 2617083..2617499 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDW56_RS12895 (2617545) 2617545..2617721 - 177 WP_063085535.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDW56_RS12900 (2617943) 2617943..2618173 + 231 WP_000494244.1 YncJ family protein -
QDW56_RS12905 (2618265) 2618265..2620226 - 1962 WP_063085534.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDW56_RS12910 (2620299) 2620299..2620835 - 537 WP_000429507.1 DNA-binding transcriptional regulator SutR -
QDW56_RS12915 (2620927) 2620927..2622098 + 1172 Protein_2528 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.78 Da        Isoelectric Point: 11.5666

>T277614 WP_063085535.1 NZ_CP122673:c2617721-2617545 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPNDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277614 WP_001270286.1 NZ_CP122673:c2617499-2617083 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6S5Q3

Antitoxin

Source ID Structure

References