Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2529442..2531030 Replicon chromosome
Accession NZ_CP122673
Organism Escherichia coli strain ETEC4071

Toxin (Protein)


Gene name hipA Uniprot ID A0A3A6RNL0
Locus tag QDW56_RS12500 Protein ID WP_063085289.1
Coordinates 2529708..2531030 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QDW56_RS12495 Protein ID WP_001296726.1
Coordinates 2529442..2529708 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW56_RS12495 (2529442) 2529442..2529708 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QDW56_RS12500 (2529708) 2529708..2531030 + 1323 WP_063085289.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QDW56_RS12505 (2531428) 2531428..2532325 - 898 Protein_2446 LysR substrate-binding domain-containing protein -
QDW56_RS12510 (2532465) 2532465..2532773 + 309 WP_001221046.1 hypothetical protein -
QDW56_RS12515 (2532782) 2532782..2533471 + 690 WP_000801314.1 type 1 glutamine amidotransferase domain-containing protein -
QDW56_RS12520 (2533533) 2533533..2534480 + 948 WP_063085290.1 aldo/keto reductase -
QDW56_RS12525 (2534583) 2534583..2534738 + 156 WP_001327998.1 hypothetical protein -
QDW56_RS12530 (2534698) 2534698..2535117 + 420 WP_001314733.1 amidohydrolase family protein -
QDW56_RS12535 (2535107) 2535107..2535259 + 153 WP_001314732.1 amidohydrolase family protein -
QDW56_RS12540 (2535409) 2535409..2535981 + 573 WP_000789914.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49313.91 Da        Isoelectric Point: 8.5849

>T277613 WP_063085289.1 NZ_CP122673:2529708-2531030 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDHVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT277613 WP_001296726.1 NZ_CP122673:2529442-2529708 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6RNL0

Antitoxin

Source ID Structure

References