Detailed information of TA system TA027761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 1112805..1114042
• Replicon: chromosome
• Accession: NC_017905
• Organism: Streptococcus parasanguinis FW213

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: I1ZM15
• Locus tag: SPAF_RS05610
• Protein ID: WP_014713362.1
• Coordinates: 1112805..1113566 (-)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: SPAF_RS05615
• Protein ID: WP_014713363.1
• Coordinates: 1113566..1114042 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPAF_RS05595	1108621..1108986	-	366	WP_000263039.1	MobC family plasmid mobilization relaxosome protein	-
SPAF_RS05600	1108996..1109355	-	360	WP_014713360.1	hypothetical protein	-
SPAF_RS05605	1110279..1112777	-	2499	WP_014713361.1	AAA family ATPase	-
SPAF_RS05610	1112805..1113566	-	762	WP_014713362.1	zeta toxin family protein	Toxin
SPAF_RS05615	1113566..1114042	-	477	WP_014713363.1	helix-turn-helix domain-containing protein	Antitoxin
SPAF_RS05620	1114112..1114384	-	273	WP_014713364.1	hypothetical protein	-
SPAF_RS05625	1114422..1114805	-	384	WP_014713365.1	hypothetical protein	-
SPAF_RS05630	1114802..1115035	-	234	WP_014713366.1	hypothetical protein	-
SPAF_RS05635	1115086..1116171	-	1086	WP_014713367.1	toprim domain-containing protein	-
SPAF_RS05640	1116181..1116822	-	642	WP_014713368.1	hypothetical protein	-
SPAF_RS05645	1116915..1117643	-	729	WP_006149384.1	ABC transporter permease	-
SPAF_RS05650	1117640..1118389	-	750	WP_029689695.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29007.94 Da
• Isoelectric Point: 6.5927

>T27761 WP_014713362.1 NC_017905:c1113566-1112805 [Streptococcus parasanguinis FW213]
MEIQDYTDSAFKHALARNVRSLTRGEKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQSNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKSKGYEVQLALIATKPELSYLSTLIRYEE
LYAINPHQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
KVGEKRLNELLEK

Nucleotide

• Length: 762 bp

>T27761 NC_017905:c1113566-1112805 [Streptococcus parasanguinis FW213]
ATGGAAATCCAAGATTATACCGATAGTGCATTCAAACATGCTTTAGCTCGGAACGTTCGCTCACTGACAAGAGGAGAAAA
GTCCAGTAAGCAACCTATAGCGATCTTGCTTGGAGGGCAAAGTGGAGCTGGTAAGACTACTATTCATCGTATTAAACAGA
AAGAATTTCAATCAAATATTGTTATCATAGATGGAGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAGCTTCAGCAA
GAATATGGCAAAGATAGTGTTGAATACACCAAAGATTTTGCGGGGAAAATGGTAGAGTCTTTAGTAACCGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGGACCTTACGAACGATAGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAGTA
AGGGATATGAAGTACAATTAGCCTTAATTGCGACAAAGCCCGAATTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTGTACGCTATCAATCCACATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGCGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCAAGAGTTACTCTTTGGGGAGTGGAGTCAGGTAGAGAAAGAGATGTTG
AAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18214.61 Da
• Isoelectric Point: 4.4188

>AT27761 WP_014713363.1 NC_017905:c1114042-1113566 [Streptococcus parasanguinis FW213]
MIGKNIKSLRKTHDLTQPEFAQIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRKVA

Nucleotide

• Length: 477 bp

>AT27761 NC_017905:c1114042-1113566 [Streptococcus parasanguinis FW213]
ATGATTGGAAAAAACATAAAATCCTTACGTAAAACACATGACTTGACCCAACCCGAATTTGCCCAAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACGGAACTAATAGACATCATTTGTCAAAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTTAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGATTTGATTCATACGAATATCTATCTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGAAGGTAGCCTAA

Structures

Toxin

• AlphaFold DB: I1ZM15