Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 144225..145126 | Replicon | plasmid unnamed5 |
| Accession | NZ_CP122665 | ||
| Organism | Escherichia coli strain ETEC4073 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | QDY26_RS26010 | Protein ID | WP_100160654.1 |
| Coordinates | 144668..145126 (+) | Length | 153 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | QDY26_RS26005 | Protein ID | WP_022652121.1 |
| Coordinates | 144225..144671 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QDY26_RS25970 (QDY26_25970) | 139717..140094 | + | 378 | WP_015063074.1 | hypothetical protein | - |
| QDY26_RS25975 (QDY26_25975) | 140230..140664 | + | 435 | WP_015063073.1 | hypothetical protein | - |
| QDY26_RS25980 (QDY26_25980) | 140728..140985 | + | 258 | WP_022652126.1 | hypothetical protein | - |
| QDY26_RS25985 (QDY26_25985) | 141101..141736 | + | 636 | WP_015063032.1 | hypothetical protein | - |
| QDY26_RS25990 (QDY26_25990) | 141798..142409 | + | 612 | WP_022652124.1 | hypothetical protein | - |
| QDY26_RS25995 (QDY26_25995) | 142396..143664 | + | 1269 | WP_015063031.1 | DNA methyltransferase | - |
| QDY26_RS26000 (QDY26_26000) | 143840..144148 | + | 309 | WP_022652122.1 | hypothetical protein | - |
| QDY26_RS26005 (QDY26_26005) | 144225..144671 | + | 447 | WP_022652121.1 | DUF2384 domain-containing protein | Antitoxin |
| QDY26_RS26010 (QDY26_26010) | 144668..145126 | + | 459 | WP_100160654.1 | RES family NAD+ phosphorylase | Toxin |
| QDY26_RS26015 (QDY26_26015) | 145729..146061 | + | 333 | WP_022652118.1 | hypothetical protein | - |
| QDY26_RS26020 (QDY26_26020) | 146118..146381 | + | 264 | WP_058658227.1 | hypothetical protein | - |
| QDY26_RS26025 (QDY26_26025) | 146611..147417 | + | 807 | WP_015063028.1 | hypothetical protein | - |
| QDY26_RS26030 (QDY26_26030) | 147464..147910 | + | 447 | WP_015063027.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | tet(B) / dfrA1 / ant(3'')-Ia / qacE / sul1 / blaTEM-1A | - | 1..222416 | 222416 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 153 a.a. Molecular weight: 16756.16 Da Isoelectric Point: 4.4964
>T277602 WP_100160654.1 NZ_CP122665:144668-145126 [Escherichia coli]
VILYRMTKTRYITTAWSGLGAKEAGGRWNSVGTALVYLSETASLTMLETLVHINAPQLLDAYTLLSIDVPDDQIQAFDLN
LLPPGWASEDAPAELALYGDNWAESGSSVALRIPSALSPVEFNYLLNPAHPAIFDLMKTVQKIPYQFETRLK
VILYRMTKTRYITTAWSGLGAKEAGGRWNSVGTALVYLSETASLTMLETLVHINAPQLLDAYTLLSIDVPDDQIQAFDLN
LLPPGWASEDAPAELALYGDNWAESGSSVALRIPSALSPVEFNYLLNPAHPAIFDLMKTVQKIPYQFETRLK
Download Length: 459 bp
Antitoxin
Download Length: 149 a.a. Molecular weight: 16606.03 Da Isoelectric Point: 7.4048
>AT277602 WP_022652121.1 NZ_CP122665:144225-144671 [Escherichia coli]
MTMKVFSPDLSKMNPHGLWQVVGLDNDGIALMDKISHGLEGKVAHSISEWANITPSELRKMSGIPNTTFNRSVKARFTAD
QSERLVRIIRVIERAVELFEGDKEAAQKWMNEPNRGLSWKTPADVVSSETGALEVMRLITRIEHGVYS
MTMKVFSPDLSKMNPHGLWQVVGLDNDGIALMDKISHGLEGKVAHSISEWANITPSELRKMSGIPNTTFNRSVKARFTAD
QSERLVRIIRVIERAVELFEGDKEAAQKWMNEPNRGLSWKTPADVVSSETGALEVMRLITRIEHGVYS
Download Length: 447 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|