Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 21313..21914 Replicon plasmid unnamed4
Accession NZ_CP122664
Organism Escherichia coli strain ETEC4073

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag QDY26_RS25015 Protein ID WP_001216045.1
Coordinates 21313..21693 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag QDY26_RS25020 Protein ID WP_001190712.1
Coordinates 21693..21914 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY26_RS24985 (QDY26_24985) 16440..16670 - 231 Protein_14 ash family protein -
QDY26_RS24990 (QDY26_24990) 16754..18196 - 1443 WP_236495866.1 terminase -
QDY26_RS24995 (QDY26_24995) 18238..19431 - 1194 WP_000219618.1 hypothetical protein -
QDY26_RS25000 (QDY26_25000) 19517..19969 - 453 WP_032192895.1 Late promoter-activating protein -
QDY26_RS25005 (QDY26_25005) 20058..21101 - 1044 WP_046788789.1 DUF968 domain-containing protein -
QDY26_RS25010 (QDY26_25010) 21129..21308 - 180 WP_000113018.1 hypothetical protein -
QDY26_RS25015 (QDY26_25015) 21313..21693 - 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
QDY26_RS25020 (QDY26_25020) 21693..21914 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QDY26_RS25025 (QDY26_25025) 22097..23653 + 1557 WP_046788805.1 type I restriction-modification system subunit M -
QDY26_RS25030 (QDY26_25030) 23650..24843 + 1194 WP_077788586.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..67952 67952


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T277601 WP_001216045.1 NZ_CP122664:c21693-21313 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT277601 WP_001190712.1 NZ_CP122664:c21914-21693 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References