Detailed information of TA system TA027759

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 424713..425247
• Replicon: chromosome
• Accession: NC_017905
• Organism: Streptococcus parasanguinis FW213

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I1ZK52
• Locus tag: SPAF_RS02205
• Protein ID: WP_014712870.1
• Coordinates: 424969..425247 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I1ZK51
• Locus tag: SPAF_RS02200
• Protein ID: WP_009732165.1
• Coordinates: 424713..424976 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPAF_RS02195	420179..424573	+	4395	WP_014712869.1	PolC-type DNA polymerase III	-
SPAF_RS02200	424713..424976	+	264	WP_009732165.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SPAF_RS02205	424969..425247	+	279	WP_014712870.1	type II toxin-antitoxin system YafQ family toxin	Toxin
SPAF_RS10810	425265..425414	+	150	WP_014712871.1	hypothetical protein	-
SPAF_RS02215	425565..428417	+	2853	WP_014712872.1	AAA family ATPase	-
SPAF_RS02220	428673..429914	+	1242	WP_041826221.1	aminopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-86)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 11025.87 Da
• Isoelectric Point: 9.8360

>T27759 WP_014712870.1 NC_017905:424969-425247 [Streptococcus parasanguinis FW213]
VLKIRYHKQFKKDFKLAMKRGLKANLLEEVLNFLVQEKELPVRYRDHQLTNSNHFQGVRECHIQPDWLLVYKVDKDELIL
NLLRTGSHSDLL

Nucleotide

• Length: 279 bp

>T27759 NC_017905:424969-425247 [Streptococcus parasanguinis FW213]
GTGCTTAAGATTCGTTATCATAAACAGTTTAAAAAAGATTTTAAGTTAGCAATGAAGCGTGGTTTAAAGGCAAACTTGTT
AGAAGAAGTTTTGAATTTTCTGGTTCAAGAAAAAGAACTTCCTGTCAGATATCGTGACCATCAACTGACCAACTCCAATC
ATTTCCAAGGTGTTCGGGAGTGTCATATCCAGCCCGATTGGCTTTTGGTTTACAAAGTAGATAAGGATGAATTGATTTTA
AACTTGCTGAGGACAGGAAGTCACAGTGATTTGTTGTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9986.37 Da
• Isoelectric Point: 4.5219

>AT27759 WP_009732165.1 NC_017905:424713-424976 [Streptococcus parasanguinis FW213]
MSKTSMSIRLDSEVKEQAQLVFNHLGMDMTTAINIFLRQAIQYQGLPFDVRLDDHGKLLQVVTDVEQNRNMSQPFESVSD
LMEDLRA

Nucleotide

• Length: 264 bp

>AT27759 NC_017905:424713-424976 [Streptococcus parasanguinis FW213]
ATGTCAAAGACGAGCATGAGTATCCGTTTGGATAGTGAGGTTAAGGAGCAGGCCCAACTGGTGTTCAATCATTTGGGAAT
GGATATGACAACAGCTATCAACATTTTCCTTCGTCAGGCTATTCAATATCAGGGCTTACCTTTTGATGTTCGATTAGATG
ATCATGGGAAGTTGCTCCAAGTAGTAACGGATGTAGAGCAAAATCGGAATATGAGTCAACCCTTTGAATCAGTCTCAGAC
TTGATGGAGGACTTGCGTGCTTAA

Structures

Toxin

• AlphaFold DB: I1ZK52

Antitoxin

• AlphaFold DB: I1ZK51