Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3531611..3532229 Replicon chromosome
Accession NZ_CP122660
Organism Escherichia coli strain ETEC4073

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDY26_RS17425 Protein ID WP_001291435.1
Coordinates 3532011..3532229 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDY26_RS17420 Protein ID WP_000344800.1
Coordinates 3531611..3531985 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY26_RS17410 (3526700) 3526700..3527893 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDY26_RS17415 (3527916) 3527916..3531065 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QDY26_RS17420 (3531611) 3531611..3531985 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDY26_RS17425 (3532011) 3532011..3532229 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDY26_RS17430 (3532401) 3532401..3532952 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDY26_RS17435 (3533068) 3533068..3533538 + 471 WP_000136192.1 YlaC family protein -
QDY26_RS17440 (3533702) 3533702..3535252 + 1551 WP_001372457.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDY26_RS17445 (3535294) 3535294..3535647 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDY26_RS17455 (3536026) 3536026..3536337 + 312 WP_000409911.1 MGMT family protein -
QDY26_RS17460 (3536368) 3536368..3536940 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277589 WP_001291435.1 NZ_CP122660:3532011-3532229 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277589 WP_000344800.1 NZ_CP122660:3531611-3531985 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References