Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2422559..2423197 Replicon chromosome
Accession NZ_CP122660
Organism Escherichia coli strain ETEC4073

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QDY26_RS11825 Protein ID WP_000813794.1
Coordinates 2423021..2423197 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDY26_RS11820 Protein ID WP_001270286.1
Coordinates 2422559..2422975 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY26_RS11800 (2417711) 2417711..2418652 - 942 WP_001251304.1 ABC transporter permease -
QDY26_RS11805 (2418653) 2418653..2419666 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QDY26_RS11810 (2419684) 2419684..2420829 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QDY26_RS11815 (2421074) 2421074..2422480 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
QDY26_RS11820 (2422559) 2422559..2422975 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDY26_RS11825 (2423021) 2423021..2423197 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDY26_RS11830 (2423419) 2423419..2423649 + 231 WP_000494244.1 YncJ family protein -
QDY26_RS11835 (2423741) 2423741..2425702 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDY26_RS11840 (2425775) 2425775..2426311 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QDY26_RS11845 (2426403) 2426403..2427578 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T277586 WP_000813794.1 NZ_CP122660:c2423197-2423021 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277586 WP_001270286.1 NZ_CP122660:c2422975-2422559 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References