Detailed information of TA system TA027758

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 4075843..4076369
• Replicon: chromosome
• Accession: NC_017904
• Organism: Mycobacterium sp. MOTT36Y

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: S4ZDZ6
• Locus tag: W7S_RS18360
• Protein ID: WP_008259048.1
• Coordinates: 4076067..4076369 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: S4ZFD0
• Locus tag: W7S_RS18355
• Protein ID: WP_008259047.1
• Coordinates: 4075843..4076070 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
W7S_RS18330	4070920..4071840	-	921	WP_008259041.1	MinD/ParA family protein	-
W7S_RS18335	4072085..4073116	-	1032	WP_008259042.1	6-phosphofructokinase	-
W7S_RS18340	4073160..4074653	-	1494	WP_008259043.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	-
W7S_RS18345	4074650..4074949	-	300	WP_008259044.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
W7S_RS18350	4075049..4075705	+	657	WP_085976512.1	amino acid-binding protein	-
W7S_RS18355	4075843..4076070	+	228	WP_008259047.1	ribbon-helix-helix protein, CopG family	Antitoxin
W7S_RS18360	4076067..4076369	+	303	WP_008259048.1	hypothetical protein	Toxin
W7S_RS18365	4076485..4076793	-	309	WP_008259049.1	hypothetical protein	-
W7S_RS18370	4076852..4079773	-	2922	WP_014712101.1	MMPL family transporter	-
W7S_RS18375	4079770..4080216	-	447	WP_193375010.1	transport acessory protein MmpS	-
W7S_RS18380	4080421..4080939	+	519	WP_014712102.1	pyridoxamine 5'-phosphate oxidase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10473.31 Da
• Isoelectric Point: 4.5636

>T27758 WP_008259048.1 NC_017904:4076067-4076369 [Mycobacterium sp. MOTT36Y]
MIAPGDIAPRRDTRRDLYVAVLSNAIHLAANTGRVIVCPFIPGKIPDDTMAMVVPLTQPEGTLLPELVQWLPTSALGEPI
GAVSAAALSEAMSIVTALIT

Nucleotide

• Length: 303 bp

>T27758 NC_017904:4076067-4076369 [Mycobacterium sp. MOTT36Y]
ATGATCGCGCCGGGCGACATCGCGCCGCGGCGAGACACCCGCCGCGACCTCTACGTCGCGGTGCTCTCCAACGCGATCCA
CCTCGCGGCCAACACTGGTCGCGTCATCGTCTGCCCGTTCATCCCTGGGAAAATCCCCGACGACACGATGGCCATGGTCG
TTCCGCTCACGCAGCCCGAAGGCACTCTTCTCCCCGAACTGGTGCAGTGGCTGCCGACTTCGGCGCTCGGTGAACCGATC
GGGGCCGTGTCGGCGGCCGCGCTTAGCGAGGCGATGTCGATCGTGACCGCGCTGATCACGTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8173.14 Da
• Isoelectric Point: 6.4608

>AT27758 WP_008259047.1 NC_017904:4075843-4076070 [Mycobacterium sp. MOTT36Y]
MAKEKISVTVDAAVLADADSDAKAAGLNRSEMIERALRNEHLRRALHTYTTRTAPALNIDSYAGQVYEANRAADL

Nucleotide

• Length: 228 bp

>AT27758 NC_017904:4075843-4076070 [Mycobacterium sp. MOTT36Y]
ATGGCCAAAGAGAAGATTTCTGTCACCGTCGACGCCGCCGTGCTCGCCGACGCCGACTCCGACGCCAAAGCGGCCGGACT
GAATCGCTCCGAGATGATCGAGCGGGCACTGCGCAATGAGCATCTACGTCGCGCGCTTCATACCTATACGACGCGGACCG
CACCAGCGCTCAACATCGACTCCTACGCCGGGCAAGTGTATGAAGCCAACCGGGCCGCGGACCTATGA

Structures

Toxin

• AlphaFold DB: S4ZDZ6

Antitoxin

• AlphaFold DB: S4ZFD0