Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 59357..59916 Replicon plasmid unnamed2
Accession NZ_CP122657
Organism Escherichia coli strain ETEC4074

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QDW60_RS25155 Protein ID WP_032084131.1
Coordinates 59641..59916 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QDW60_RS25150 Protein ID WP_032084130.1
Coordinates 59357..59641 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW60_RS25125 (56747) 56747..57439 + 693 WP_062873939.1 fimbrial chaperone -
QDW60_RS25130 (57504) 57504..57935 + 432 WP_282953961.1 F18 fimbrial protein FedE -
QDW60_RS25135 (58086) 58086..58928 + 843 WP_062873937.1 hypothetical protein -
QDW60_RS25140 (58995) 58995..59120 - 126 Protein_75 IS256 family transposase -
QDW60_RS25145 (59192) 59192..59272 - 81 Protein_76 ATP-binding protein -
QDW60_RS25150 (59357) 59357..59641 + 285 WP_032084130.1 ribbon-helix-helix domain-containing protein Antitoxin
QDW60_RS25155 (59641) 59641..59916 + 276 WP_032084131.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDW60_RS25160 (60022) 60022..60225 + 204 Protein_79 hypothetical protein -
QDW60_RS25165 (60572) 60572..60918 + 347 Protein_80 DUF6404 family protein -
QDW60_RS25170 (60936) 60936..61370 - 435 Protein_81 hypothetical protein -
QDW60_RS25175 (61654) 61654..62577 - 924 WP_032084040.1 hypothetical protein -
QDW60_RS25180 (63621) 63621..63824 + 204 Protein_83 integrase core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - estIa 1..83893 83893


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10765.45 Da        Isoelectric Point: 9.9324

>T277573 WP_032084131.1 NZ_CP122657:59641-59916 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFSGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10517.92 Da        Isoelectric Point: 5.6558

>AT277573 WP_032084130.1 NZ_CP122657:59357-59641 [Escherichia coli]
MQMKNNSAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQTW
ADSLNTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References