Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 31678..32303 Replicon plasmid unnamed2
Accession NZ_CP122657
Organism Escherichia coli strain ETEC4074

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QDW60_RS24985 Protein ID WP_000911317.1
Coordinates 31678..32076 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag QDW60_RS24990 Protein ID WP_000450532.1
Coordinates 32076..32303 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW60_RS24970 (28010) 28010..28519 + 510 WP_032082913.1 conjugal transfer entry exclusion protein TraS -
QDW60_RS24975 (28533) 28533..29264 + 732 WP_024187508.1 conjugal transfer complement resistance protein TraT -
QDW60_RS24980 (29516) 29516..31669 + 2154 WP_062873762.1 type IV conjugative transfer system coupling protein TraD -
QDW60_RS24985 (31678) 31678..32076 - 399 WP_000911317.1 type II toxin-antitoxin system VapC family toxin Toxin
QDW60_RS24990 (32076) 32076..32303 - 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - estIa 1..83893 83893


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14857.14 Da        Isoelectric Point: 8.5264

>T277572 WP_000911317.1 NZ_CP122657:c32076-31678 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT277572 WP_000450532.1 NZ_CP122657:c32303-32076 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References