Detailed information of TA system TA027757

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 2610851..2611843
• Replicon: chromosome
• Accession: NC_017904
• Organism: Mycobacterium sp. MOTT36Y

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: S4ZAV9
• Locus tag: W7S_RS11925
• Protein ID: WP_014711570.1
• Coordinates: 2611265..2611843 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: I2ADH5
• Locus tag: W7S_RS11920
• Protein ID: WP_008256419.1
• Coordinates: 2610851..2611240 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
W7S_RS11900	2606002..2606670	-	669	WP_179945108.1	hypothetical protein	-
W7S_RS11905	2606750..2608267	+	1518	WP_014711567.1	carboxylesterase/lipase family protein	-
W7S_RS11910	2608286..2610289	+	2004	WP_014711568.1	phosphotransferase	-
W7S_RS11915	2610286..2610780	+	495	WP_014711569.1	gluconokinase	-
W7S_RS11920	2610851..2611240	+	390	WP_008256419.1	hypothetical protein	Antitoxin
W7S_RS11925	2611265..2611843	+	579	WP_014711570.1	zeta toxin family protein	Toxin
W7S_RS11930	2611853..2612920	-	1068	WP_020822441.1	DoxX family membrane protein	-
W7S_RS11935	2613016..2613576	+	561	WP_014711572.1	pyrazinamidase PncA	-
W7S_RS11940	2613576..2614376	+	801	WP_020822443.1	nuclear transport factor 2 family protein	-
W7S_RS11945	2614388..2614738	-	351	WP_008256426.1	DoxX family protein	-
W7S_RS11950	2614904..2615875	+	972	WP_008256428.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-137)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21009.00 Da
• Isoelectric Point: 11.0233

>T27757 WP_014711570.1 NC_017904:2611265-2611843 [Mycobacterium sp. MOTT36Y]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGESAGRAYEAAQIAADTRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLTGGTTIGSPDWPAWTPGALRSRWAD

Nucleotide

• Length: 579 bp

>T27757 NC_017904:2611265-2611843 [Mycobacterium sp. MOTT36Y]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGACGAAATCGCAAGGCAGCGCTGGCCGGGGGAGTCGGCGGGGCGCGCCTACGAGG
CCGCGCAAATCGCCGCCGACACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTTATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCACCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTCCGAGAGCGCCATC
GTCGCTTGTGGACGCCAGTCACCGACGCCATCGCGCTATCCGACGTCGCCACCGTCTACGACAACAGCCGCCTTCGCGGG
CCGCGCATCGTCGCCCGCCTCACCGGCGGCACGACGATCGGTTCACCGGACTGGCCCGCGTGGACGCCAGGGGCCTTGCG
GTCACGCTGGGCGGACTAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13518.97 Da
• Isoelectric Point: 5.1668

>AT27757 WP_008256419.1 NC_017904:2610851-2611240 [Mycobacterium sp. MOTT36Y]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAAMAGQLATGELTVEEGVVFNAEI
SAAIEESLVHANYGATLAGHGVTTVALNEDGDIVEHLPDGAAVMLARGR

Nucleotide

• Length: 390 bp

>AT27757 NC_017904:2610851-2611240 [Mycobacterium sp. MOTT36Y]
ATGGCCGACGCTCCCGATCGTGTGACCCGGGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGATGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCGGCTATTGAAGAAAGCCTGGTGCACGCCAACTACGGGGCGACGCTGGCCGGGCATGGGGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCTGCCCGATGGCGCCGCCGTAATGCTGGCGCGCGGGCGCTGA

Structures

Toxin

• AlphaFold DB: S4ZAV9

Antitoxin

• AlphaFold DB: I2ADH5