Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4494142..4494639 Replicon chromosome
Accession NZ_CP122655
Organism Escherichia coli strain ETEC4074

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDW60_RS22455 Protein ID WP_001173343.1
Coordinates 4494142..4494315 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDW60_RS22460 Protein ID WP_000398619.1
Coordinates 4494343..4494639 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW60_RS22445 (4490812) 4490812..4492269 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
QDW60_RS22450 (4492506) 4492506..4494023 + 1518 WP_032083613.1 lysine--tRNA ligase -
QDW60_RS22455 (4494142) 4494142..4494315 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDW60_RS22460 (4494343) 4494343..4494639 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDW60_RS22465 (4494866) 4494866..4495138 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
QDW60_RS22470 (4495150) 4495150..4495380 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
QDW60_RS22475 (4495561) 4495561..4497192 + 1632 WP_032083612.1 sensor histidine kinase -
QDW60_RS22480 (4497189) 4497189..4497908 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T277569 WP_001173343.1 NZ_CP122655:c4494315-4494142 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277569 WP_000398619.1 NZ_CP122655:c4494639-4494343 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References