Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3622262..3622880 Replicon chromosome
Accession NZ_CP122655
Organism Escherichia coli strain ETEC4074

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDW60_RS18110 Protein ID WP_001291435.1
Coordinates 3622662..3622880 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDW60_RS18105 Protein ID WP_000344800.1
Coordinates 3622262..3622636 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW60_RS18095 (3617351) 3617351..3618544 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDW60_RS18100 (3618567) 3618567..3621716 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QDW60_RS18105 (3622262) 3622262..3622636 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDW60_RS18110 (3622662) 3622662..3622880 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDW60_RS18115 (3623052) 3623052..3623603 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDW60_RS18120 (3623719) 3623719..3624189 + 471 WP_000136192.1 YlaC family protein -
QDW60_RS18125 (3624353) 3624353..3625903 + 1551 WP_032083478.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDW60_RS18130 (3625945) 3625945..3626298 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDW60_RS18140 (3626677) 3626677..3626988 + 312 WP_032083470.1 MGMT family protein -
QDW60_RS18145 (3627019) 3627019..3627591 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277566 WP_001291435.1 NZ_CP122655:3622662-3622880 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277566 WP_000344800.1 NZ_CP122655:3622262-3622636 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References