Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 874594..875248 Replicon chromosome
Accession NZ_CP122655
Organism Escherichia coli strain ETEC4074

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QDW60_RS04315 Protein ID WP_000244777.1
Coordinates 874841..875248 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QDW60_RS04310 Protein ID WP_000354046.1
Coordinates 874594..874860 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW60_RS04285 (869762) 869762..870505 + 744 WP_032083429.1 SDR family oxidoreductase -
QDW60_RS04290 (870562) 870562..871995 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
QDW60_RS04295 (872040) 872040..872351 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
QDW60_RS04300 (872515) 872515..873174 + 660 WP_000250274.1 hemolysin III family protein -
QDW60_RS04305 (873370) 873370..874351 - 982 Protein_845 tRNA-modifying protein YgfZ -
QDW60_RS04310 (874594) 874594..874860 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QDW60_RS04315 (874841) 874841..875248 + 408 WP_000244777.1 protein YgfX Toxin
QDW60_RS04320 (875288) 875288..875809 - 522 WP_001055874.1 flavodoxin FldB -
QDW60_RS04325 (875921) 875921..876817 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QDW60_RS04330 (876842) 876842..877552 + 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDW60_RS04335 (877558) 877558..879291 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T277554 WP_000244777.1 NZ_CP122655:874841-875248 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT277554 WP_000354046.1 NZ_CP122655:874594-874860 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References