Detailed information of TA system TA027755

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1136849..1137393
• Replicon: chromosome
• Accession: NC_017904
• Organism: Mycobacterium sp. MOTT36Y

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: W7S_RS25895
• Protein ID: WP_081490150.1
• Coordinates: 1137127..1137393 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I2A9X5
• Locus tag: W7S_RS05615
• Protein ID: WP_008254382.1
• Coordinates: 1136849..1137130 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
W7S_RS05595	1132619..1133218	-	600	WP_008254377.1	lipid droplet-associated protein	-
W7S_RS05600	1133308..1134306	+	999	WP_008254378.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
W7S_RS05605	1134353..1135498	-	1146	WP_193375016.1	hypothetical protein	-
W7S_RS05610	1135628..1136701	+	1074	WP_008254380.1	redox-regulated ATPase YchF	-
W7S_RS05615	1136849..1137130	+	282	WP_008254382.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
W7S_RS25895	1137127..1137393	+	267	WP_081490150.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
W7S_RS25900	1137556..1137762	+	207	WP_008254383.1	type II toxin-antitoxin system VapB family antitoxin	-
W7S_RS05620	1137823..1138374	+	552	WP_008254384.1	VOC family protein	-
W7S_RS05625	1138453..1138851	+	399	WP_014711055.1	VOC family protein	-
W7S_RS25905	1138923..1139306	+	384	WP_170320554.1	hypothetical protein	-
W7S_RS27280	1139392..1139751	+	360	WP_170320555.1	hypothetical protein	-
W7S_RS05635	1139936..1140469	+	534	WP_168160311.1	C40 family peptidase	-
W7S_RS05640	1140833..1141156	+	324	WP_008254389.1	antibiotic biosynthesis monooxygenase	-
W7S_RS05645	1141194..1142027	-	834	WP_008254390.1	SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (30-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10314.87 Da
• Isoelectric Point: 10.5138

>T27755 WP_081490150.1 NC_017904:1137127-1137393 [Mycobacterium sp. MOTT36Y]
IAAYRIELTRRARRSLSEELPEEVAAACWEFITNVLAHNPLRVGKALRADLAGRFSARRGDFRVIYEIHDDKVVIRIVDV
RHRRDVYR

Nucleotide

• Length: 267 bp

>T27755 NC_017904:1137127-1137393 [Mycobacterium sp. MOTT36Y]
ATAGCGGCGTACCGGATCGAGCTGACTCGCCGCGCTCGCAGAAGCCTGTCTGAGGAACTGCCCGAAGAGGTAGCGGCTGC
CTGTTGGGAATTCATCACGAACGTACTGGCGCACAATCCGTTACGGGTTGGAAAGGCGCTGCGGGCTGACCTCGCGGGCA
GGTTCTCCGCCCGGCGCGGGGATTTCAGGGTGATCTACGAAATCCACGACGACAAGGTCGTGATTCGGATTGTCGACGTG
CGTCACAGGCGAGACGTTTATCGGTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10090.48 Da
• Isoelectric Point: 4.5257

>AT27755 WP_008254382.1 NC_017904:1136849-1137130 [Mycobacterium sp. MOTT36Y]
METLPLAEVRANLSKLVDEAVRTHQRVEVTRQGRRAAVLLSADDYDSIMETLDILGDAAAMAALREADADIAAGRLYPAD
QVEAELRAKGIVK

Nucleotide

• Length: 282 bp

>AT27755 NC_017904:1136849-1137130 [Mycobacterium sp. MOTT36Y]
ATGGAGACTCTTCCGTTGGCGGAAGTTCGAGCCAACCTCTCAAAGTTGGTCGACGAGGCCGTGCGCACGCATCAGCGGGT
CGAAGTCACCCGGCAAGGACGTCGAGCGGCAGTTCTTCTGAGTGCCGACGACTACGACTCGATCATGGAGACGTTGGACA
TCCTCGGCGACGCGGCTGCCATGGCTGCACTGCGGGAGGCGGACGCCGACATCGCCGCTGGGCGGCTCTACCCCGCCGAC
CAGGTTGAGGCGGAACTCCGCGCGAAGGGGATCGTGAAATAG

Structures

Antitoxin

• AlphaFold DB: I2A9X5