Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 58821..59368 Replicon plasmid unnamed2
Accession NZ_CP122654
Organism Escherichia coli strain ETEC4075

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag QDW61_RS25195 Protein ID WP_001384452.1
Coordinates 59090..59368 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag QDW61_RS25190 Protein ID WP_000079928.1
Coordinates 58821..59090 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW61_RS25170 (53963) 53963..54250 - 288 WP_000074849.1 conjugal transfer protein TraA -
QDW61_RS25175 (54168) 54168..54398 - 231 WP_228772074.1 ash family protein -
QDW61_RS25180 (55404) 55404..56435 + 1032 WP_000907875.1 plasmid replication initiator RepA -
QDW61_RS25185 (57418) 57418..58428 - 1011 WP_096984501.1 IS110 family transposase -
QDW61_RS25190 (58821) 58821..59090 + 270 WP_000079928.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QDW61_RS25195 (59090) 59090..59368 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
QDW61_RS25200 (59408) 59408..60256 + 849 WP_001057996.1 3'-5' exonuclease -
QDW61_RS25205 (60493) 60493..60618 - 126 Protein_61 MerR family transcriptional regulator -
QDW61_RS25210 (60613) 60613..62223 + 1611 Protein_62 DDE-type integrase/transposase/recombinase -
QDW61_RS25215 (62226) 62226..63086 + 861 WP_000344784.1 TniB family NTP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / qacE / ant(3'')-Ia / dfrA1 / aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1B - 1..109222 109222


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T277549 WP_001384452.1 NZ_CP122654:59090-59368 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10175.50 Da        Isoelectric Point: 7.3210

>AT277549 WP_000079928.1 NZ_CP122654:58821-59090 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References