Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4538179..4538676 Replicon chromosome
Accession NZ_CP122652
Organism Escherichia coli strain ETEC4075

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDW61_RS22350 Protein ID WP_001173343.1
Coordinates 4538179..4538352 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDW61_RS22355 Protein ID WP_000398619.1
Coordinates 4538380..4538676 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW61_RS22340 (4534849) 4534849..4536306 + 1458 WP_001550473.1 dipeptide/tripeptide permease DtpC -
QDW61_RS22345 (4536543) 4536543..4538060 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDW61_RS22350 (4538179) 4538179..4538352 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDW61_RS22355 (4538380) 4538380..4538676 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDW61_RS22360 (4538903) 4538903..4539175 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QDW61_RS22365 (4539187) 4539187..4539417 - 231 WP_001550470.1 4Fe-4S mono-cluster protein YjdI -
QDW61_RS22370 (4539597) 4539597..4541228 + 1632 WP_001216482.1 sensor histidine kinase -
QDW61_RS22375 (4541225) 4541225..4541944 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4503127..4538676 35549


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T277543 WP_001173343.1 NZ_CP122652:c4538352-4538179 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277543 WP_000398619.1 NZ_CP122652:c4538676-4538380 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References