Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3761515..3762133 Replicon chromosome
Accession NZ_CP122652
Organism Escherichia coli strain ETEC4075

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDW61_RS18580 Protein ID WP_001291435.1
Coordinates 3761915..3762133 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDW61_RS18575 Protein ID WP_000344800.1
Coordinates 3761515..3761889 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW61_RS18565 (3756604) 3756604..3757797 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDW61_RS18570 (3757820) 3757820..3760969 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
QDW61_RS18575 (3761515) 3761515..3761889 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDW61_RS18580 (3761915) 3761915..3762133 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDW61_RS18585 (3762305) 3762305..3762856 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDW61_RS18590 (3762972) 3762972..3763442 + 471 WP_063085325.1 YlaC family protein -
QDW61_RS18595 (3763606) 3763606..3765156 + 1551 WP_063085326.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDW61_RS18600 (3765198) 3765198..3765551 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDW61_RS18610 (3765930) 3765930..3766241 + 312 WP_000409911.1 MGMT family protein -
QDW61_RS18615 (3766272) 3766272..3766844 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277539 WP_001291435.1 NZ_CP122652:3761915-3762133 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277539 WP_000344800.1 NZ_CP122652:3761515-3761889 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References