Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3333476..3334181 Replicon chromosome
Accession NZ_CP122652
Organism Escherichia coli strain ETEC4075

Toxin (Protein)


Gene name relE Uniprot ID A0A3A6SJV3
Locus tag QDW61_RS16595 Protein ID WP_063085620.1
Coordinates 3333476..3333862 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QDW61_RS16600 Protein ID WP_001280945.1
Coordinates 3333852..3334181 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW61_RS16575 (3329480) 3329480..3330106 + 627 WP_001314584.1 glutathione S-transferase GstB -
QDW61_RS16580 (3330103) 3330103..3331218 - 1116 WP_063085618.1 aldose sugar dehydrogenase YliI -
QDW61_RS16585 (3331329) 3331329..3331712 - 384 WP_000497137.1 biofilm formation regulator BssR -
QDW61_RS16590 (3331925) 3331925..3333250 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
QDW61_RS16595 (3333476) 3333476..3333862 + 387 WP_063085620.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDW61_RS16600 (3333852) 3333852..3334181 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
QDW61_RS16605 (3334251) 3334251..3335579 - 1329 WP_000086873.1 GGDEF domain-containing protein -
QDW61_RS16610 (3335587) 3335587..3337935 - 2349 WP_021523051.1 EAL domain-containing protein -
QDW61_RS16615 (3338113) 3338113..3339024 - 912 WP_001236019.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14280.45 Da        Isoelectric Point: 9.9296

>T277538 WP_063085620.1 NZ_CP122652:3333476-3333862 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSTKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT277538 WP_001280945.1 NZ_CP122652:3333852-3334181 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6SJV3

Antitoxin

Source ID Structure

References