Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2638983..2639621 Replicon chromosome
Accession NZ_CP122652
Organism Escherichia coli strain ETEC4075

Toxin (Protein)


Gene name hicA Uniprot ID A0A3A6S5Q3
Locus tag QDW61_RS13000 Protein ID WP_063085535.1
Coordinates 2639445..2639621 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDW61_RS12995 Protein ID WP_001270286.1
Coordinates 2638983..2639399 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW61_RS12975 (2634135) 2634135..2635076 - 942 WP_063085538.1 ABC transporter permease -
QDW61_RS12980 (2635077) 2635077..2636090 - 1014 WP_063085537.1 ABC transporter ATP-binding protein -
QDW61_RS12985 (2636108) 2636108..2637253 - 1146 WP_000047450.1 ABC transporter substrate-binding protein -
QDW61_RS12990 (2637498) 2637498..2638904 - 1407 WP_063085536.1 PLP-dependent aminotransferase family protein -
QDW61_RS12995 (2638983) 2638983..2639399 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDW61_RS13000 (2639445) 2639445..2639621 - 177 WP_063085535.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDW61_RS13005 (2639843) 2639843..2640073 + 231 WP_000494244.1 YncJ family protein -
QDW61_RS13010 (2640165) 2640165..2642126 - 1962 WP_063085534.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDW61_RS13015 (2642199) 2642199..2642735 - 537 WP_000429507.1 DNA-binding transcriptional regulator SutR -
QDW61_RS13020 (2642827) 2642827..2643998 + 1172 Protein_2550 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.78 Da        Isoelectric Point: 11.5666

>T277533 WP_063085535.1 NZ_CP122652:c2639621-2639445 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPNDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277533 WP_001270286.1 NZ_CP122652:c2639399-2638983 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6S5Q3

Antitoxin

Source ID Structure

References