Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 3063600..3064125 Replicon chromosome
Accession NC_017857
Organism Methylophaga nitratireducenticrescens

Toxin (Protein)


Gene name relE Uniprot ID A0A7U5TWC5
Locus tag Q7A_RS14725 Protein ID WP_041354619.1
Coordinates 3063841..3064125 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U5Z438
Locus tag Q7A_RS14720 Protein ID WP_041354617.1
Coordinates 3063600..3063851 (+) Length 84 a.a.

Genomic Context

Q7A_RS14695Q7A_RS14700Q7A_RS14705Q7A_RS14720Q7A_RS14725Q7A_RS14730Q7A_RS15150Q7A_RS14740Q7A_RS14750Q7A_RS14690Q7A_RS14710Q7A_RS14715Q7A_RS14745Q7A_RS14755Q7A_RS14760
Location: 3060012..3060575 (564 bp)
Type: Others
Protein ID: WP_014707629.1
Location: 3060572..3061771 (1200 bp)
Type: Others
Protein ID: WP_014707630.1
Location: 3061768..3062574 (807 bp)
Type: Others
Protein ID: WP_014707631.1
Location: 3063600..3063851 (252 bp)
Type: Antitoxin
Protein ID: WP_041354617.1
Location: 3063841..3064125 (285 bp)
Type: Toxin
Protein ID: WP_041354619.1
Location: 3064181..3064516 (336 bp)
Type: Others
Protein ID: WP_041354621.1
Location: 3064779..3064997 (219 bp)
Type: Others
Protein ID: WP_014707634.1
Location: 3065035..3065529 (495 bp)
Type: Others
Protein ID: WP_041355218.1
Location: 3066486..3066929 (444 bp)
Type: Others
Protein ID: WP_202971540.1
Location: 3059096..3059896 (801 bp)
Type: Others
Protein ID: WP_041355216.1
Location: 3062902..3063192 (291 bp)
Type: Others
Protein ID: WP_014707632.1
Location: 3063185..3063406 (222 bp)
Type: Others
Protein ID: WP_007113097.1
Location: 3065597..3066046 (450 bp)
Type: Others
Protein ID: WP_041354623.1
Location: 3066945..3067262 (318 bp)
Type: Others
Protein ID: WP_014707638.1
Location: 3067262..3067507 (246 bp)
Type: Others
Protein ID: WP_014707639.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
Q7A_RS146903059096..3059896-801WP_041355216.1lipopolysaccharide core heptose(I) kinase RfaP-
Q7A_RS146953060012..3060575+564WP_014707629.1D-sedoheptulose 7-phosphate isomerase-
Q7A_RS147003060572..3061771+1200WP_014707630.1FAD-dependent oxidoreductase-
Q7A_RS147053061768..3062574+807WP_014707631.1aldo/keto reductase-
Q7A_RS147103062902..3063192-291WP_014707632.1type II toxin-antitoxin system RelE/ParE family toxin-
Q7A_RS147153063185..3063406-222WP_007113097.1hypothetical protein-
Q7A_RS147203063600..3063851+252WP_041354617.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
Q7A_RS147253063841..3064125+285WP_041354619.1type II toxin-antitoxin system RelE/ParE family toxinToxin
Q7A_RS147303064181..3064516+336WP_041354621.1hypothetical protein-
Q7A_RS151503064779..3064997+219WP_014707634.1hypothetical protein-
Q7A_RS147403065035..3065529+495WP_041355218.1hypothetical protein-
Q7A_RS147453065597..3066046-450WP_041354623.1hypothetical protein-
Q7A_RS147503066486..3066929+444WP_202971540.1dioxygenase-
Q7A_RS147553066945..3067262-318WP_014707638.1CcdB family protein-
Q7A_RS147603067262..3067507-246WP_014707639.1type II toxin-antitoxin system CcdA family antitoxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-73)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10963.14 Da        Isoelectric Point: 10.8430

>T27753 WP_041354619.1 NC_017857:3063841-3064125 [Methylophaga nitratireducenticrescens]
MTYKLKFVPSALKEWKKLSAPIRSQFKKKLEERLINPRIPSAKLGGYSSVYKIKLRSAGYRLVYEVVDEELVIYVLVAGK
RKKGKVYQTLKDRK

Download         Length: 285 bp

>T27753 NC_017857:3063841-3064125 [Methylophaga nitratireducenticrescens]
ATGACCTATAAGCTGAAATTTGTCCCTTCAGCACTGAAGGAATGGAAGAAGCTGAGCGCTCCTATAAGAAGTCAGTTTAA
GAAGAAACTTGAAGAGCGACTTATTAATCCAAGAATACCTTCAGCAAAGCTTGGAGGCTATAGCTCCGTGTACAAAATTA
AACTACGATCAGCTGGCTACCGTTTGGTTTACGAAGTGGTAGATGAAGAGCTAGTCATCTATGTCCTTGTCGCTGGTAAA
CGAAAGAAAGGGAAGGTCTACCAGACATTGAAGGACCGAAAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9155.41 Da        Isoelectric Point: 4.3076

>AT27753 WP_041354617.1 NC_017857:3063600-3063851 [Methylophaga nitratireducenticrescens]
MRQVLADFSVSISELKKNPSSLLSQACGSPIAVLNHNKPAAYFIPADTYEAMMEMIEDYELGKLVEERHGERAEAVAVSL
DDL

Download         Length: 252 bp

>AT27753 NC_017857:3063600-3063851 [Methylophaga nitratireducenticrescens]
ATGCGCCAAGTATTAGCAGATTTCTCTGTAAGCATCTCAGAATTAAAGAAAAATCCATCATCATTGCTATCCCAGGCCTG
TGGCTCCCCTATTGCTGTCCTGAACCATAACAAGCCTGCTGCATACTTCATACCTGCAGATACGTATGAAGCTATGATGG
AAATGATTGAGGATTACGAACTGGGCAAGCTGGTCGAAGAGCGCCATGGTGAGCGCGCAGAAGCCGTCGCGGTGTCACTG
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U5TWC5

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U5Z438

References