Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 3063600..3064125 Replicon chromosome
Accession NC_017857
Organism Methylophaga nitratireducenticrescens

Toxin (Protein)


Gene name relE Uniprot ID A0A7U5TWC5
Locus tag Q7A_RS14725 Protein ID WP_041354619.1
Coordinates 3063841..3064125 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U5Z438
Locus tag Q7A_RS14720 Protein ID WP_041354617.1
Coordinates 3063600..3063851 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Q7A_RS14690 3059096..3059896 - 801 WP_041355216.1 lipopolysaccharide core heptose(I) kinase RfaP -
Q7A_RS14695 3060012..3060575 + 564 WP_014707629.1 D-sedoheptulose 7-phosphate isomerase -
Q7A_RS14700 3060572..3061771 + 1200 WP_014707630.1 FAD-dependent oxidoreductase -
Q7A_RS14705 3061768..3062574 + 807 WP_014707631.1 aldo/keto reductase -
Q7A_RS14710 3062902..3063192 - 291 WP_014707632.1 type II toxin-antitoxin system RelE/ParE family toxin -
Q7A_RS14715 3063185..3063406 - 222 WP_007113097.1 hypothetical protein -
Q7A_RS14720 3063600..3063851 + 252 WP_041354617.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Q7A_RS14725 3063841..3064125 + 285 WP_041354619.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Q7A_RS14730 3064181..3064516 + 336 WP_041354621.1 hypothetical protein -
Q7A_RS15150 3064779..3064997 + 219 WP_014707634.1 hypothetical protein -
Q7A_RS14740 3065035..3065529 + 495 WP_041355218.1 hypothetical protein -
Q7A_RS14745 3065597..3066046 - 450 WP_041354623.1 hypothetical protein -
Q7A_RS14750 3066486..3066929 + 444 WP_202971540.1 dioxygenase -
Q7A_RS14755 3066945..3067262 - 318 WP_014707638.1 CcdB family protein -
Q7A_RS14760 3067262..3067507 - 246 WP_014707639.1 type II toxin-antitoxin system CcdA family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-73)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10963.14 Da        Isoelectric Point: 10.8430

>T27753 WP_041354619.1 NC_017857:3063841-3064125 [Methylophaga nitratireducenticrescens]
MTYKLKFVPSALKEWKKLSAPIRSQFKKKLEERLINPRIPSAKLGGYSSVYKIKLRSAGYRLVYEVVDEELVIYVLVAGK
RKKGKVYQTLKDRK

Download         Length: 285 bp

>T27753 NC_017857:3063841-3064125 [Methylophaga nitratireducenticrescens]
ATGACCTATAAGCTGAAATTTGTCCCTTCAGCACTGAAGGAATGGAAGAAGCTGAGCGCTCCTATAAGAAGTCAGTTTAA
GAAGAAACTTGAAGAGCGACTTATTAATCCAAGAATACCTTCAGCAAAGCTTGGAGGCTATAGCTCCGTGTACAAAATTA
AACTACGATCAGCTGGCTACCGTTTGGTTTACGAAGTGGTAGATGAAGAGCTAGTCATCTATGTCCTTGTCGCTGGTAAA
CGAAAGAAAGGGAAGGTCTACCAGACATTGAAGGACCGAAAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9155.41 Da        Isoelectric Point: 4.3076

>AT27753 WP_041354617.1 NC_017857:3063600-3063851 [Methylophaga nitratireducenticrescens]
MRQVLADFSVSISELKKNPSSLLSQACGSPIAVLNHNKPAAYFIPADTYEAMMEMIEDYELGKLVEERHGERAEAVAVSL
DDL

Download         Length: 252 bp

>AT27753 NC_017857:3063600-3063851 [Methylophaga nitratireducenticrescens]
ATGCGCCAAGTATTAGCAGATTTCTCTGTAAGCATCTCAGAATTAAAGAAAAATCCATCATCATTGCTATCCCAGGCCTG
TGGCTCCCCTATTGCTGTCCTGAACCATAACAAGCCTGCTGCATACTTCATACCTGCAGATACGTATGAAGCTATGATGG
AAATGATTGAGGATTACGAACTGGGCAAGCTGGTCGAAGAGCGCCATGGTGAGCGCGCAGAAGCCGTCGCGGTGTCACTG
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U5TWC5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U5Z438

References