Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 959722..960376 Replicon chromosome
Accession NZ_CP122652
Organism Escherichia coli strain ETEC4075

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QDW61_RS04605 Protein ID WP_000244781.1
Coordinates 959969..960376 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QDW61_RS04600 Protein ID WP_000354046.1
Coordinates 959722..959988 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW61_RS04580 (955810) 955810..957243 - 1434 WP_063085817.1 6-phospho-beta-glucosidase BglA -
QDW61_RS04585 (957288) 957288..957599 + 312 WP_001182952.1 N(4)-acetylcytidine aminohydrolase -
QDW61_RS04590 (957763) 957763..958422 + 660 WP_000250269.1 hemolysin III family protein -
QDW61_RS04595 (958499) 958499..959479 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
QDW61_RS04600 (959722) 959722..959988 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QDW61_RS04605 (959969) 959969..960376 + 408 WP_000244781.1 protein YgfX Toxin
QDW61_RS04610 (960416) 960416..960937 - 522 WP_001055888.1 flavodoxin FldB -
QDW61_RS04615 (961049) 961049..961945 + 897 WP_000806652.1 site-specific tyrosine recombinase XerD -
QDW61_RS04620 (961970) 961970..962680 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDW61_RS04625 (962686) 962686..964419 + 1734 WP_000813177.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T277525 WP_000244781.1 NZ_CP122652:959969-960376 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT277525 WP_000354046.1 NZ_CP122652:959722-959988 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References