Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 723728..724563 Replicon chromosome
Accession NZ_CP122652
Organism Escherichia coli strain ETEC4075

Toxin (Protein)


Gene name yeeV Uniprot ID S1EZ92
Locus tag QDW61_RS03475 Protein ID WP_000854726.1
Coordinates 724186..724563 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag QDW61_RS03470 Protein ID WP_064559964.1
Coordinates 723728..724096 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW61_RS03435 (718905) 718905..719777 + 873 WP_096098506.1 GTPase family protein -
QDW61_RS03440 (720150) 720150..721247 + 1098 Protein_673 AIDA repeat-containing protein -
QDW61_RS03445 (721317) 721317..721658 + 342 Protein_674 DUF932 domain-containing protein -
QDW61_RS03450 (721749) 721749..722234 + 486 WP_096098508.1 antirestriction protein -
QDW61_RS03455 (722249) 722249..722725 + 477 WP_140431832.1 RadC family protein -
QDW61_RS03460 (722794) 722794..723015 + 222 WP_000692353.1 DUF987 domain-containing protein -
QDW61_RS03465 (723034) 723034..723678 + 645 WP_016240659.1 hypothetical protein -
QDW61_RS03470 (723728) 723728..724096 + 369 WP_064559964.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QDW61_RS03475 (724186) 724186..724563 + 378 WP_000854726.1 TA system toxin CbtA family protein Toxin
QDW61_RS03480 (724560) 724560..725048 + 489 WP_063080559.1 DUF5983 family protein -
QDW61_RS03485 (725060) 725060..725257 + 198 WP_063080560.1 DUF957 domain-containing protein -
QDW61_RS03490 (725342) 725342..726187 + 846 WP_049038750.1 DUF4942 domain-containing protein -
QDW61_RS03500 (726475) 726475..726981 + 507 WP_063086280.1 G/U mismatch-specific DNA glycosylase -
QDW61_RS03505 (727060) 727060..728901 - 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14164.10 Da        Isoelectric Point: 7.8045

>T277524 WP_000854726.1 NZ_CP122652:724186-724563 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13904.64 Da        Isoelectric Point: 5.9652

>AT277524 WP_064559964.1 NZ_CP122652:723728-724096 [Escherichia coli]
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRDGIRGRFRDVDAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1EZ92

Antitoxin

Source ID Structure

References