Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 154236..154848 Replicon chromosome
Accession NZ_CP122652
Organism Escherichia coli strain ETEC4075

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag QDW61_RS00690 Protein ID WP_000833473.1
Coordinates 154236..154421 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1V3VHB3
Locus tag QDW61_RS00695 Protein ID WP_000499746.1
Coordinates 154438..154848 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW61_RS00675 (149755) 149755..151146 + 1392 WP_063084986.1 L-seryl-tRNA(Sec) selenium transferase -
QDW61_RS00680 (151143) 151143..152993 + 1851 WP_096098561.1 selenocysteine-specific translation elongation factor -
QDW61_RS00685 (153022) 153022..153719 + 698 WP_236281370.1 IS1 family transposase -
QDW61_RS00690 (154236) 154236..154421 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
QDW61_RS00695 (154438) 154438..154848 + 411 WP_000499746.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QDW61_RS00700 (154920) 154920..156884 - 1965 WP_096098550.1 glycoside hydrolase family 127 protein -
QDW61_RS00705 (156895) 156895..158295 - 1401 WP_096098549.1 MFS transporter -
QDW61_RS00710 (158521) 158521..159336 + 816 WP_000891838.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T277522 WP_000833473.1 NZ_CP122652:154236-154421 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15290.22 Da        Isoelectric Point: 4.5486

>AT277522 WP_000499746.1 NZ_CP122652:154438-154848 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDYAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A1V3VHB3

References