Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 27359..27906 Replicon plasmid unnamed3
Accession NZ_CP122651
Organism Escherichia coli strain ETEC4077

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QDY56_RS27370 Protein ID WP_244461648.1
Coordinates 27628..27906 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A2H4TKA5
Locus tag QDY56_RS27365 Protein ID WP_000079937.1
Coordinates 27359..27628 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY56_RS27350 (QDY56_27350) 23403..23963 - 561 WP_001161490.1 recombinase family protein -
QDY56_RS27355 (QDY56_27355) 24273..25850 + 1578 WP_001323889.1 PAS domain-containing methyl-accepting chemotaxis protein -
QDY56_RS27360 (QDY56_27360) 26146..27183 + 1038 WP_032083970.1 DNA-binding protein -
QDY56_RS27365 (QDY56_27365) 27359..27628 + 270 WP_000079937.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QDY56_RS27370 (QDY56_27370) 27628..27906 + 279 WP_244461648.1 type II toxin-antitoxin system toxin YacB Toxin
QDY56_RS27375 (QDY56_27375) 28215..29357 + 1143 WP_158649904.1 YiiX/YebB-like N1pC/P60 family cysteine hydrolase -
QDY56_RS27380 (QDY56_27380) 29330..29434 + 105 Protein_29 hypothetical protein -
QDY56_RS27385 (QDY56_27385) 29446..29751 + 306 WP_000482654.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..31040 31040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10732.29 Da        Isoelectric Point: 8.4615

>T277521 WP_244461648.1 NZ_CP122651:27628-27906 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLTAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10174.56 Da        Isoelectric Point: 10.1760

>AT277521 WP_000079937.1 NZ_CP122651:27359-27628 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLKHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2H4TKA5

References