Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4623769..4624266 Replicon chromosome
Accession NZ_CP122648
Organism Escherichia coli strain ETEC4077

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDY56_RS22905 Protein ID WP_001173343.1
Coordinates 4623769..4623942 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDY56_RS22910 Protein ID WP_000398619.1
Coordinates 4623970..4624266 (-) Length 99 a.a.

Genomic Context


QDY56_RS22895QDY56_RS22900QDY56_RS22925QDY56_RS22930QDY56_RS22905QDY56_RS22910QDY56_RS22915QDY56_RS22920
Location: 4620439..4621896 (1458 bp)
Type: Others
Protein ID: WP_001550473.1
Location: 4622133..4623650 (1518 bp)
Type: Others
Protein ID: WP_001295074.1
Location: 4625187..4626818 (1632 bp)
Type: Others
Protein ID: WP_001216482.1
Location: 4626815..4627534 (720 bp)
Type: Others
Protein ID: WP_000611288.1
Location: 4623769..4623942 (174 bp)
Type: Toxin
Protein ID: WP_001173343.1
Location: 4623970..4624266 (297 bp)
Type: Antitoxin
Protein ID: WP_000398619.1
Location: 4624493..4624765 (273 bp)
Type: Others
Protein ID: WP_000405647.1
Location: 4624777..4625007 (231 bp)
Type: Others
Protein ID: WP_001550470.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QDY56_RS22895 (4620439)4620439..4621896+1458WP_001550473.1dipeptide/tripeptide permease DtpC-
QDY56_RS22900 (4622133)4622133..4623650+1518WP_001295074.1lysine--tRNA ligase-
QDY56_RS22905 (4623769)4623769..4623942-174WP_001173343.1type V toxin-antitoxin system toxin GhoTToxin
QDY56_RS22910 (4623970)4623970..4624266-297WP_000398619.1type V toxin-antitoxin system endoribonuclease antitoxin GhoSAntitoxin
QDY56_RS22915 (4624493)4624493..4624765-273WP_000405647.1GNAT family N-acetyltransferase-
QDY56_RS22920 (4624777)4624777..4625007-231WP_001550470.14Fe-4S mono-cluster protein YjdI-
QDY56_RS22925 (4625187)4625187..4626818+1632WP_001216482.1sensor histidine kinase-
QDY56_RS22930 (4626815)4626815..4627534+720WP_000611288.1two-component system response regulator DcuR-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--4585070..462426639196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-57)

Antitoxin

(5-94)


Sequences


Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T277518 WP_001173343.1 NZ_CP122648:c4623942-4623769 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp


Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277518 WP_000398619.1 NZ_CP122648:c4624266-4623970 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A7U9QI41


Antitoxin

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Source
ID
Structure
PDB2LLZ
AlphaFold DBA0A7U9QBH6

References