Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4395160..4395736 Replicon chromosome
Accession NZ_CP122648
Organism Escherichia coli strain ETEC4077

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QDY56_RS21710 Protein ID WP_001297643.1
Coordinates 4395449..4395736 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A080I7H7
Locus tag QDY56_RS21705 Protein ID WP_000063160.1
Coordinates 4395160..4395462 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY56_RS21690 (4391756) 4391756..4393906 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QDY56_RS21695 (4393956) 4393956..4394159 + 204 WP_000467859.1 YbdD/YjiX family protein -
QDY56_RS21700 (4394170) 4394170..4395126 + 957 WP_001297640.1 GTPase -
QDY56_RS21705 (4395160) 4395160..4395462 - 303 WP_000063160.1 BrnA antitoxin family protein Antitoxin
QDY56_RS21710 (4395449) 4395449..4395736 - 288 WP_001297643.1 BrnT family toxin Toxin
QDY56_RS21715 (4395935) 4395935..4396632 - 698 Protein_4255 IS1 family transposase -
QDY56_RS21720 (4396689) 4396689..4396784 + 96 Protein_4256 dienelactone hydrolase family protein -
QDY56_RS21725 (4396930) 4396930..4398162 + 1233 WP_024186283.1 multidrug efflux MFS transporter MdtM -
QDY56_RS21730 (4398203) 4398203..4399483 + 1281 WP_001037400.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T277516 WP_001297643.1 NZ_CP122648:c4395736-4395449 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11552.01 Da        Isoelectric Point: 9.4646

>AT277516 WP_000063160.1 NZ_CP122648:c4395462-4395160 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALTNKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A080I7H7

References