Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3816753..3817371 Replicon chromosome
Accession NZ_CP122648
Organism Escherichia coli strain ETEC4077

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDY56_RS18930 Protein ID WP_001291435.1
Coordinates 3817153..3817371 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDY56_RS18925 Protein ID WP_000344800.1
Coordinates 3816753..3817127 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY56_RS18915 (3811842) 3811842..3813035 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDY56_RS18920 (3813058) 3813058..3816207 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
QDY56_RS18925 (3816753) 3816753..3817127 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDY56_RS18930 (3817153) 3817153..3817371 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDY56_RS18935 (3817543) 3817543..3818094 + 552 WP_063118620.1 maltose O-acetyltransferase -
QDY56_RS18940 (3818210) 3818210..3818680 + 471 WP_063085325.1 YlaC family protein -
QDY56_RS18945 (3818844) 3818844..3820394 + 1551 WP_063085326.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDY56_RS18950 (3820436) 3820436..3820789 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDY56_RS18960 (3821168) 3821168..3821479 + 312 WP_000409911.1 MGMT family protein -
QDY56_RS18965 (3821510) 3821510..3822082 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277513 WP_001291435.1 NZ_CP122648:3817153-3817371 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277513 WP_000344800.1 NZ_CP122648:3816753-3817127 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References