Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3381591..3382296 Replicon chromosome
Accession NZ_CP122648
Organism Escherichia coli strain ETEC4077

Toxin (Protein)


Gene name relE Uniprot ID A0A3A6SJV3
Locus tag QDY56_RS16930 Protein ID WP_063085620.1
Coordinates 3381591..3381977 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QDY56_RS16935 Protein ID WP_001280945.1
Coordinates 3381967..3382296 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY56_RS16910 (3377595) 3377595..3378221 + 627 WP_001314584.1 glutathione S-transferase GstB -
QDY56_RS16915 (3378218) 3378218..3379333 - 1116 WP_063085618.1 aldose sugar dehydrogenase YliI -
QDY56_RS16920 (3379444) 3379444..3379827 - 384 WP_000497137.1 biofilm formation regulator BssR -
QDY56_RS16925 (3380040) 3380040..3381365 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
QDY56_RS16930 (3381591) 3381591..3381977 + 387 WP_063085620.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDY56_RS16935 (3381967) 3381967..3382296 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
QDY56_RS16940 (3382366) 3382366..3383694 - 1329 WP_000086873.1 GGDEF domain-containing protein -
QDY56_RS16945 (3383702) 3383702..3386050 - 2349 WP_021523051.1 EAL domain-containing protein -
QDY56_RS16950 (3386228) 3386228..3387139 - 912 WP_001236019.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14280.45 Da        Isoelectric Point: 9.9296

>T277512 WP_063085620.1 NZ_CP122648:3381591-3381977 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSTKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT277512 WP_001280945.1 NZ_CP122648:3381967-3382296 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6SJV3

Antitoxin

Source ID Structure

References