Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2667759..2668397 Replicon chromosome
Accession NZ_CP122648
Organism Escherichia coli strain ETEC4077

Toxin (Protein)


Gene name hicA Uniprot ID A0A3A6S5Q3
Locus tag QDY56_RS13270 Protein ID WP_063085535.1
Coordinates 2668221..2668397 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDY56_RS13265 Protein ID WP_001270286.1
Coordinates 2667759..2668175 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY56_RS13240 (2662807) 2662807..2662926 - 120 Protein_2596 ABC transporter permease -
QDY56_RS13245 (2662899) 2662899..2663852 - 954 WP_242378934.1 ABC transporter permease -
QDY56_RS13250 (2663853) 2663853..2664866 - 1014 WP_063085537.1 ABC transporter ATP-binding protein -
QDY56_RS13255 (2664884) 2664884..2666029 - 1146 WP_000047450.1 ABC transporter substrate-binding protein -
QDY56_RS13260 (2666274) 2666274..2667680 - 1407 WP_063085536.1 PLP-dependent aminotransferase family protein -
QDY56_RS13265 (2667759) 2667759..2668175 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDY56_RS13270 (2668221) 2668221..2668397 - 177 WP_063085535.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDY56_RS13275 (2668619) 2668619..2668849 + 231 WP_000494244.1 YncJ family protein -
QDY56_RS13280 (2668941) 2668941..2670902 - 1962 WP_063085534.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDY56_RS13285 (2670975) 2670975..2671511 - 537 WP_000429507.1 DNA-binding transcriptional regulator SutR -
QDY56_RS13290 (2671603) 2671603..2672774 + 1172 Protein_2606 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.78 Da        Isoelectric Point: 11.5666

>T277510 WP_063085535.1 NZ_CP122648:c2668397-2668221 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPNDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277510 WP_001270286.1 NZ_CP122648:c2668175-2667759 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6S5Q3

Antitoxin

Source ID Structure

References