Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2587988..2589576 Replicon chromosome
Accession NZ_CP122648
Organism Escherichia coli strain ETEC4077

Toxin (Protein)


Gene name hipA Uniprot ID A0A3A6RNL0
Locus tag QDY56_RS12900 Protein ID WP_063085289.1
Coordinates 2588254..2589576 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QDY56_RS12895 Protein ID WP_001296726.1
Coordinates 2587988..2588254 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY56_RS12895 (2587988) 2587988..2588254 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QDY56_RS12900 (2588254) 2588254..2589576 + 1323 WP_063085289.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QDY56_RS12905 (2589974) 2589974..2590871 - 898 Protein_2529 LysR substrate-binding domain-containing protein -
QDY56_RS12910 (2591011) 2591011..2591319 + 309 WP_001221046.1 hypothetical protein -
QDY56_RS12915 (2591328) 2591328..2592017 + 690 WP_000801314.1 type 1 glutamine amidotransferase domain-containing protein -
QDY56_RS12920 (2592079) 2592079..2593026 + 948 WP_063085290.1 aldo/keto reductase -
QDY56_RS12925 (2593129) 2593129..2593284 + 156 WP_001327998.1 hypothetical protein -
QDY56_RS12930 (2593244) 2593244..2593663 + 420 WP_001314733.1 amidohydrolase family protein -
QDY56_RS12935 (2593653) 2593653..2593805 + 153 WP_001314732.1 amidohydrolase family protein -
QDY56_RS12940 (2593955) 2593955..2594527 + 573 WP_000789914.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49313.91 Da        Isoelectric Point: 8.5849

>T277509 WP_063085289.1 NZ_CP122648:2588254-2589576 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDHVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT277509 WP_001296726.1 NZ_CP122648:2587988-2588254 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6RNL0

Antitoxin

Source ID Structure

References