Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4614640..4615137 Replicon chromosome
Accession NZ_CP122643
Organism Escherichia coli strain ETEC4079

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDW55_RS22855 Protein ID WP_001173343.1
Coordinates 4614640..4614813 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDW55_RS22860 Protein ID WP_000398619.1
Coordinates 4614841..4615137 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW55_RS22845 (4611310) 4611310..4612767 + 1458 WP_001550473.1 dipeptide/tripeptide permease DtpC -
QDW55_RS22850 (4613004) 4613004..4614521 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDW55_RS22855 (4614640) 4614640..4614813 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDW55_RS22860 (4614841) 4614841..4615137 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDW55_RS22865 (4615364) 4615364..4615636 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QDW55_RS22870 (4615648) 4615648..4615878 - 231 WP_001550470.1 4Fe-4S mono-cluster protein YjdI -
QDW55_RS22875 (4616058) 4616058..4617689 + 1632 WP_001216482.1 sensor histidine kinase -
QDW55_RS22880 (4617686) 4617686..4618405 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4575878..4615137 39259


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T277493 WP_001173343.1 NZ_CP122643:c4614813-4614640 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277493 WP_000398619.1 NZ_CP122643:c4615137-4614841 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References