Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4385849..4386425 Replicon chromosome
Accession NZ_CP122643
Organism Escherichia coli strain ETEC4079

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QDW55_RS21655 Protein ID WP_001297643.1
Coordinates 4386138..4386425 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A080I7H7
Locus tag QDW55_RS21650 Protein ID WP_000063160.1
Coordinates 4385849..4386151 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW55_RS21635 (4382445) 4382445..4384595 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QDW55_RS21640 (4384645) 4384645..4384848 + 204 WP_000467859.1 YbdD/YjiX family protein -
QDW55_RS21645 (4384859) 4384859..4385815 + 957 WP_001297640.1 GTPase -
QDW55_RS21650 (4385849) 4385849..4386151 - 303 WP_000063160.1 BrnA antitoxin family protein Antitoxin
QDW55_RS21655 (4386138) 4386138..4386425 - 288 WP_001297643.1 BrnT family toxin Toxin
QDW55_RS21660 (4386624) 4386624..4387321 - 698 Protein_4245 IS1 family transposase -
QDW55_RS21665 (4387378) 4387378..4387473 + 96 Protein_4246 dienelactone hydrolase family protein -
QDW55_RS21670 (4387619) 4387619..4388851 + 1233 WP_024186283.1 multidrug efflux MFS transporter MdtM -
QDW55_RS21675 (4388892) 4388892..4390172 + 1281 WP_001037400.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T277491 WP_001297643.1 NZ_CP122643:c4386425-4386138 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11552.01 Da        Isoelectric Point: 9.4646

>AT277491 WP_000063160.1 NZ_CP122643:c4386151-4385849 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALTNKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A080I7H7

References