Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 859388..860145 Replicon chromosome
Accession NC_017857
Organism Methylophaga nitratireducenticrescens

Toxin (Protein)


Gene name tacT Uniprot ID I1XH20
Locus tag Q7A_RS04085 Protein ID WP_014706064.1
Coordinates 859388..859879 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A7U5TSP1
Locus tag Q7A_RS04090 Protein ID WP_041354352.1
Coordinates 859870..860145 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Q7A_RS04060 854666..855037 + 372 WP_041354349.1 hypothetical protein -
Q7A_RS04065 855164..855793 - 630 WP_014706060.1 hypothetical protein -
Q7A_RS04070 855888..856634 - 747 WP_014706061.1 IS21-like element helper ATPase IstB -
Q7A_RS04075 856646..858160 - 1515 WP_014707050.1 IS21 family transposase -
Q7A_RS04080 858392..859276 - 885 WP_014706063.1 competence protein -
Q7A_RS04085 859388..859879 - 492 WP_014706064.1 GNAT family N-acetyltransferase Toxin
Q7A_RS04090 859870..860145 - 276 WP_041354352.1 DUF1778 domain-containing protein Antitoxin
Q7A_RS04095 860851..861174 - 324 WP_014706067.1 DUF2149 domain-containing protein -
Q7A_RS04100 861171..861689 - 519 WP_014706068.1 MotA/TolQ/ExbB proton channel family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(23-145)

Antitoxin

Vibrio phage ICP1, Orf50

(4-91)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17970.64 Da        Isoelectric Point: 7.4328

>T27749 WP_014706064.1 NC_017857:c859879-859388 [Methylophaga nitratireducenticrescens]
MGVSAPTPLKDDHDISQFNCGNQTLNNWLQHTALKNERHDGSRTFVVCDDKRVVGYYTLAAGAIQRLDASGKVRRNMPEP
VPVIVLGRLAVDLAYQGNRVGPGLLKDALLRVISISEQIGIKAMLVHAISEEAKNFYLHYGFTESPTNDMTLMITIKDAV
AHL

Download         Length: 492 bp

>T27749 NC_017857:c859879-859388 [Methylophaga nitratireducenticrescens]
ATGGGAGTAAGTGCCCCAACCCCATTAAAAGATGACCACGATATATCTCAATTTAATTGTGGAAATCAAACACTTAATAA
CTGGCTTCAGCACACTGCGTTAAAAAATGAACGTCATGATGGTTCAAGAACATTTGTGGTGTGTGATGATAAGCGTGTTG
TTGGTTACTATACGCTCGCAGCAGGAGCTATCCAGCGCCTTGATGCTTCTGGCAAAGTAAGAAGAAACATGCCTGAACCT
GTTCCCGTCATTGTTCTAGGTAGATTGGCTGTTGATCTAGCTTACCAGGGTAATAGGGTAGGTCCTGGTCTTCTCAAAGA
TGCCTTATTACGAGTGATTAGTATCAGCGAGCAAATTGGGATAAAAGCAATGCTTGTTCACGCTATATCTGAAGAGGCTA
AAAACTTTTATCTTCATTATGGTTTTACTGAATCACCAACTAATGACATGACATTGATGATTACTATCAAGGATGCCGTG
GCACATTTATGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10339.88 Da        Isoelectric Point: 5.1227

>AT27749 WP_041354352.1 NC_017857:c860145-859870 [Methylophaga nitratireducenticrescens]
MQETIKRQAPINLRALPAQRALIDRASQICGKSRTDFVLEAACREAENILLDQRLFFLDEQTFNAFEESLLAPVKDNPAL
RKLLASPSPWE

Download         Length: 276 bp

>AT27749 NC_017857:c860145-859870 [Methylophaga nitratireducenticrescens]
ATGCAAGAAACTATAAAAAGACAAGCACCAATTAACTTACGCGCACTGCCAGCTCAGCGCGCTTTAATTGACCGTGCGAG
CCAAATTTGTGGGAAGAGTCGTACTGATTTCGTTCTAGAAGCAGCATGTCGCGAAGCAGAGAATATCTTGTTAGACCAGC
GATTATTTTTTCTCGATGAGCAAACCTTTAATGCCTTTGAAGAAAGCTTATTAGCACCGGTTAAAGACAACCCTGCCTTA
CGTAAATTGTTGGCTAGCCCATCCCCATGGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I1XH20

Antitoxin

Source ID Structure
AlphaFold DB A0A7U5TSP1

References