Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2667487..2668125 Replicon chromosome
Accession NZ_CP122643
Organism Escherichia coli strain ETEC4079

Toxin (Protein)


Gene name hicA Uniprot ID A0A3A6S5Q3
Locus tag QDW55_RS13265 Protein ID WP_063085535.1
Coordinates 2667949..2668125 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDW55_RS13260 Protein ID WP_001270286.1
Coordinates 2667487..2667903 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW55_RS13235 (2662535) 2662535..2662654 - 120 Protein_2596 ABC transporter permease -
QDW55_RS13240 (2662627) 2662627..2663580 - 954 WP_242378934.1 ABC transporter permease -
QDW55_RS13245 (2663581) 2663581..2664594 - 1014 WP_063085537.1 ABC transporter ATP-binding protein -
QDW55_RS13250 (2664612) 2664612..2665757 - 1146 WP_000047450.1 ABC transporter substrate-binding protein -
QDW55_RS13255 (2666002) 2666002..2667408 - 1407 WP_063085536.1 PLP-dependent aminotransferase family protein -
QDW55_RS13260 (2667487) 2667487..2667903 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDW55_RS13265 (2667949) 2667949..2668125 - 177 WP_063085535.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDW55_RS13270 (2668347) 2668347..2668577 + 231 WP_000494244.1 YncJ family protein -
QDW55_RS13275 (2668669) 2668669..2670630 - 1962 WP_063085534.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDW55_RS13280 (2670703) 2670703..2671239 - 537 WP_000429507.1 DNA-binding transcriptional regulator SutR -
QDW55_RS13285 (2671331) 2671331..2672502 + 1172 Protein_2606 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.78 Da        Isoelectric Point: 11.5666

>T277485 WP_063085535.1 NZ_CP122643:c2668125-2667949 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPNDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277485 WP_001270286.1 NZ_CP122643:c2667903-2667487 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6S5Q3

Antitoxin

Source ID Structure

References