Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2587716..2589304 Replicon chromosome
Accession NZ_CP122643
Organism Escherichia coli strain ETEC4079

Toxin (Protein)


Gene name hipA Uniprot ID A0A3A6RNL0
Locus tag QDW55_RS12895 Protein ID WP_063085289.1
Coordinates 2587982..2589304 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QDW55_RS12890 Protein ID WP_001296726.1
Coordinates 2587716..2587982 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW55_RS12890 (2587716) 2587716..2587982 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QDW55_RS12895 (2587982) 2587982..2589304 + 1323 WP_063085289.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QDW55_RS12900 (2589702) 2589702..2590599 - 898 Protein_2529 LysR substrate-binding domain-containing protein -
QDW55_RS12905 (2590739) 2590739..2591047 + 309 WP_001221046.1 hypothetical protein -
QDW55_RS12910 (2591056) 2591056..2591745 + 690 WP_000801314.1 type 1 glutamine amidotransferase domain-containing protein -
QDW55_RS12915 (2591807) 2591807..2592754 + 948 WP_063085290.1 aldo/keto reductase -
QDW55_RS12920 (2592857) 2592857..2593012 + 156 WP_001327998.1 hypothetical protein -
QDW55_RS12925 (2592972) 2592972..2593391 + 420 WP_001314733.1 amidohydrolase family protein -
QDW55_RS12930 (2593381) 2593381..2593533 + 153 WP_001314732.1 amidohydrolase family protein -
QDW55_RS12935 (2593683) 2593683..2594255 + 573 WP_000789914.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49313.91 Da        Isoelectric Point: 8.5849

>T277484 WP_063085289.1 NZ_CP122643:2587982-2589304 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDHVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT277484 WP_001296726.1 NZ_CP122643:2587716-2587982 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6RNL0

Antitoxin

Source ID Structure

References