Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 915269..915923 Replicon chromosome
Accession NZ_CP122643
Organism Escherichia coli strain ETEC4079

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QDW55_RS04420 Protein ID WP_000244781.1
Coordinates 915516..915923 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QDW55_RS04415 Protein ID WP_000354046.1
Coordinates 915269..915535 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW55_RS04395 (911357) 911357..912790 - 1434 WP_063085817.1 6-phospho-beta-glucosidase BglA -
QDW55_RS04400 (912835) 912835..913146 + 312 WP_001182952.1 N(4)-acetylcytidine aminohydrolase -
QDW55_RS04405 (913310) 913310..913969 + 660 WP_000250269.1 hemolysin III family protein -
QDW55_RS04410 (914046) 914046..915026 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
QDW55_RS04415 (915269) 915269..915535 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QDW55_RS04420 (915516) 915516..915923 + 408 WP_000244781.1 protein YgfX Toxin
QDW55_RS04425 (915963) 915963..916484 - 522 WP_001055888.1 flavodoxin FldB -
QDW55_RS04430 (916596) 916596..917492 + 897 WP_000806652.1 site-specific tyrosine recombinase XerD -
QDW55_RS04435 (917517) 917517..918227 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDW55_RS04440 (918233) 918233..919966 + 1734 WP_000813177.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T277476 WP_000244781.1 NZ_CP122643:915516-915923 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT277476 WP_000354046.1 NZ_CP122643:915269-915535 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References