Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 700458..702024 Replicon chromosome
Accession NC_017857
Organism Methylophaga nitratireducenticrescens

Toxin (Protein)


Gene name hipA Uniprot ID I1XGM4
Locus tag Q7A_RS03305 Protein ID WP_014705918.1
Coordinates 700458..701771 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag Q7A_RS03310 Protein ID WP_014705919.1
Coordinates 701773..702024 (-) Length 84 a.a.

Genomic Context

Q7A_RS03280Q7A_RS03285Q7A_RS03290Q7A_RS03295Q7A_RS03300Q7A_RS15115Q7A_RS03315Q7A_RS03325Q7A_RS03330Q7A_RS03335Q7A_RS03305Q7A_RS03310
Location: 696143..696994 (852 bp)
Type: Others
Protein ID: WP_014705913.1
Location: 697396..697587 (192 bp)
Type: Others
Protein ID: WP_014705914.1
Location: 697803..698363 (561 bp)
Type: Others
Protein ID: WP_202971549.1
Location: 698371..698832 (462 bp)
Type: Others
Protein ID: WP_014705916.1
Location: 699053..700279 (1227 bp)
Type: Others
Protein ID: WP_014705917.1
Location: 702269..702427 (159 bp)
Type: Others
Protein ID: Protein_652
Location: 702429..702818 (390 bp)
Type: Others
Protein ID: WP_041354298.1
Location: 703366..703719 (354 bp)
Type: Others
Protein ID: WP_014705922.1
Location: 704099..705169 (1071 bp)
Type: Others
Protein ID: Protein_655
Location: 705333..706010 (678 bp)
Type: Others
Protein ID: WP_014705925.1
Location: 700458..701771 (1314 bp)
Type: Toxin
Protein ID: WP_014705918.1
Location: 701773..702024 (252 bp)
Type: Antitoxin
Protein ID: WP_014705919.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
Q7A_RS03280696143..696994+852WP_014705913.1OmpA family protein-
Q7A_RS03285697396..697587+192WP_014705914.1CsbD family protein-
Q7A_RS03290697803..698363+561WP_202971549.1BON domain-containing protein-
Q7A_RS03295698371..698832+462WP_014705916.1hypothetical protein-
Q7A_RS03300699053..700279+1227WP_014705917.1sigma-54 dependent transcriptional regulator-
Q7A_RS03305700458..701771-1314WP_014705918.1type II toxin-antitoxin system HipA family toxinToxin
Q7A_RS03310701773..702024-252WP_014705919.1helix-turn-helix transcriptional regulatorAntitoxin
Q7A_RS15115702269..702427+159Protein_652IS982 family transposase-
Q7A_RS03315702429..702818+390WP_041354298.1hypothetical protein-
Q7A_RS03325703366..703719+354WP_014705922.1hypothetical protein-
Q7A_RS03330704099..705169+1071Protein_655IS3 family transposase-
Q7A_RS03335705333..706010+678WP_014705925.1VTT domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--704975..705169194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(154-397)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49383.59 Da        Isoelectric Point: 6.7683

>T27747 WP_014705918.1 NC_017857:c701771-700458 [Methylophaga nitratireducenticrescens]
MGRRQHYIPLDVWISNRIVGQLIRESTGAISFIYDQRWLDWEHAFPVSLSLPLRKDRFIGARVISVFENLLPDNDGVRKR
LAERVGAYGTDAFSLLSVIGRDCIGALQFLPQGSFQETSNQLEGTVLSEHEIEVLLGELDEVPLGLQKENDFRISIAGAQ
GKTALLFHNGEWIKPTGTTPTTHILKPQIGKLSNGMDLTHSVENEFLCLKLLKNFGLRTANTEIIDFGSRRALVIERFDR
RWTADGRLIRLPQEDCCQALSIPPTRKYQSEGGPGIVEIMDLFRGSDEPTQDRMDFFMSTILFWAIGATDGHGKNFSLSL
MPGGRYRMTPLYDVLTLQPSVDAKQVAHKNYKLSMSFGKSRHYKIKEIAVRYIIETGVEAGLSRQSIAEIFEQLCKDKES
VIENTLKELPEEFPKKLLESTFTAFDKNISLLLSNSR

Download         Length: 1314 bp

>T27747 NC_017857:c701771-700458 [Methylophaga nitratireducenticrescens]
ATGGGCCGTCGTCAACACTATATCCCGCTTGATGTATGGATAAGTAACCGAATCGTCGGACAGCTTATTCGTGAAAGCAC
AGGCGCTATATCGTTTATATATGATCAACGTTGGTTAGATTGGGAGCATGCTTTTCCTGTTTCTTTATCCTTACCTCTCA
GGAAAGATCGCTTCATCGGTGCTCGGGTAATATCCGTCTTCGAGAACCTTTTACCCGATAATGACGGTGTTAGAAAAAGG
CTTGCAGAACGAGTAGGTGCATATGGCACTGATGCTTTCAGTCTGTTGTCAGTGATTGGCAGAGATTGTATTGGAGCATT
ACAGTTCCTTCCCCAGGGGAGTTTTCAAGAAACAAGTAACCAGCTTGAGGGTACTGTTTTATCAGAGCATGAAATTGAAG
TCTTACTGGGCGAGTTAGATGAGGTACCACTCGGGCTACAAAAAGAAAATGACTTTCGAATATCCATTGCTGGAGCCCAA
GGGAAGACCGCTTTGCTCTTTCATAATGGAGAGTGGATTAAACCCACAGGCACAACTCCAACAACACATATACTCAAGCC
ACAAATAGGCAAACTGTCGAATGGTATGGATCTCACCCACAGTGTTGAGAATGAATTTCTGTGTTTAAAACTCCTAAAAA
ACTTTGGTCTAAGAACAGCTAACACAGAGATCATTGATTTTGGAAGTCGTAGGGCCTTGGTGATTGAACGATTTGATAGG
AGGTGGACTGCGGATGGCAGGCTGATCCGATTGCCACAGGAAGATTGTTGCCAAGCACTCTCCATCCCACCCACGAGAAA
ATATCAAAGTGAAGGAGGTCCAGGTATTGTAGAAATAATGGACTTATTTCGTGGCAGTGATGAGCCAACGCAGGACCGGA
TGGACTTTTTCATGTCCACAATTTTATTTTGGGCTATTGGTGCCACAGATGGCCATGGTAAAAACTTTAGCTTGTCTTTA
ATGCCTGGCGGAAGATATAGAATGACGCCGCTATACGATGTCCTAACCCTACAGCCATCAGTCGATGCCAAACAAGTAGC
TCATAAGAATTACAAGCTCAGTATGAGTTTTGGTAAATCCAGACACTACAAAATTAAAGAAATTGCTGTTCGGTATATCA
TCGAGACTGGCGTTGAAGCAGGGCTTTCACGTCAATCAATCGCTGAAATTTTCGAGCAACTTTGTAAAGACAAAGAATCC
GTCATCGAAAATACGCTAAAAGAGCTTCCTGAAGAATTTCCCAAAAAATTACTGGAATCCACTTTTACAGCATTTGATAA
AAATATTTCACTATTACTAAGTAACTCTCGATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9217.60 Da        Isoelectric Point: 8.7278

>AT27747 WP_014705919.1 NC_017857:c702024-701773 [Methylophaga nitratireducenticrescens]
MKILVRSPKDLGNAIRHARKAKALTQSELASKSGIWQETISKIENGVSSTKLDTVFDLFAALDLEIHVQERSKGNISQLE
EIL

Download         Length: 252 bp

>AT27747 NC_017857:c702024-701773 [Methylophaga nitratireducenticrescens]
ATGAAGATACTGGTCAGATCGCCTAAAGATTTAGGTAATGCCATCAGGCACGCTCGTAAAGCGAAAGCCTTAACTCAAAG
TGAGTTAGCCTCAAAAAGCGGTATATGGCAGGAAACGATTTCAAAAATTGAAAATGGTGTCTCGAGCACGAAGCTGGATA
CTGTTTTTGATTTATTTGCCGCTTTGGATTTGGAAATTCATGTACAAGAGCGCAGTAAGGGTAATATCAGCCAGCTAGAG
GAAATCTTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBI1XGM4

Antitoxin

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Source
ID
Structure
No matching records found

References