277467

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 23454..24046 Replicon plasmid unnamed5
Accession NZ_CP122639
Organism Escherichia coli strain ETEC4085

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag QDW62_RS28265 Protein ID WP_000520549.1
Coordinates 23454..23702 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag QDW62_RS28270 Protein ID WP_000681613.1
Coordinates 23699..24046 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW62_RS28235 (QDW62_28235) 20331..20846 + 516 WP_001025395.1 J domain-containing protein -
QDW62_RS28240 (QDW62_28240) 20951..21493 + 543 WP_001083906.1 hypothetical protein -
QDW62_RS28245 (QDW62_28245) 21490..21741 + 252 WP_001230707.1 hypothetical protein -
QDW62_RS28250 (QDW62_28250) 21728..21955 + 228 WP_000801440.1 hypothetical protein -
QDW62_RS28255 (QDW62_28255) 22409..22708 + 300 WP_000650309.1 hypothetical protein -
QDW62_RS28260 (QDW62_28260) 22799..23149 + 351 WP_000854259.1 hypothetical protein -
QDW62_RS28265 (QDW62_28265) 23454..23702 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
QDW62_RS28270 (QDW62_28270) 23699..24046 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QDW62_RS28275 (QDW62_28275) 24407..24910 + 504 WP_089552162.1 relaxosome-coupling protein TaxA -
QDW62_RS28280 (QDW62_28280) 24914..26143 + 1230 WP_001329504.1 DNA relaxase/nickase TaxC -
QDW62_RS28285 (QDW62_28285) 26220..26486 + 267 WP_000160396.1 hypothetical protein -
QDW62_RS28290 (QDW62_28290) 26491..26724 + 234 WP_000121161.1 EexN family lipoprotein -
QDW62_RS28295 (QDW62_28295) 27080..27700 + 621 WP_000157548.1 lytic transglycosylase domain-containing protein -
QDW62_RS28300 (QDW62_28300) 27714..28040 + 327 WP_000008647.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-2.1 - 1..36533 36533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9422.08 Da        Isoelectric Point: 10.4800

>T277467 WP_000520549.1 NZ_CP122639:23454-23702 [Escherichia coli]
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL

Download         Length: 249 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13113.84 Da        Isoelectric Point: 4.6723

>AT277467 WP_000681613.1 NZ_CP122639:23699-24046 [Escherichia coli]
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References