277464

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 10952..11709 Replicon plasmid unnamed4
Accession NZ_CP122638
Organism Escherichia coli strain ETEC4085

Toxin (Protein)


Gene name tacT Uniprot ID A0A0L6ZF90
Locus tag QDW62_RS27515 Protein ID WP_000501972.1
Coordinates 11224..11709 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag QDW62_RS27510 Protein ID WP_072141942.1
Coordinates 10952..11236 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW62_RS27475 (6797) 6797..7081 + 285 WP_001398227.1 hypothetical protein -
QDW62_RS27480 (7187) 7187..8182 + 996 WP_063109503.1 hypothetical protein -
QDW62_RS27485 (8253) 8253..8381 + 129 Protein_6 Hok/Gef family protein -
QDW62_RS27490 (8626) 8626..8886 + 261 WP_000083819.1 replication regulatory protein RepA -
QDW62_RS27495 (9111) 9111..9185 + 75 WP_001365705.1 RepA leader peptide Tap -
QDW62_RS27500 (9178) 9178..10035 + 858 WP_000130999.1 incFII family plasmid replication initiator RepA -
QDW62_RS27505 (10737) 10737..10877 + 141 WP_021503378.1 hypothetical protein -
QDW62_RS27510 (10952) 10952..11236 + 285 WP_072141942.1 DUF1778 domain-containing protein Antitoxin
QDW62_RS27515 (11224) 11224..11709 + 486 WP_000501972.1 GNAT family N-acetyltransferase Toxin
QDW62_RS27520 (12035) 12035..13222 - 1188 WP_000937614.1 IS91-like element IS91 family transposase -
QDW62_RS27525 (13222) 13222..13587 - 366 WP_000124098.1 hypothetical protein -
QDW62_RS27535 (14675) 14675..15019 + 345 WP_272482423.1 adhesin biosynthesis transcription regulatory family protein -
QDW62_RS27540 (15019) 15019..15564 + 546 WP_236295085.1 K88 fimbrial protein FaeC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - faeC / faeD / faeE / faeF / faeG / faeH / faeI / faeJ / eltA 1..106966 106966


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-150)

Antitoxin

Vibrio phage ICP1, Orf50

(7-93)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17630.39 Da        Isoelectric Point: 9.9107

>T277464 WP_000501972.1 NZ_CP122638:11224-11709 [Escherichia coli]
MGCVTAPEPLSSFHQVAEFVSGEAVLDDWLKQKGLKNQALGATRTFVVCRKGTQQVVGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDASFRGKGLGADLLHDAVRRCYRVAENIGVRAIMVHALTESAKQFYIHHGFTPSKTQLQTLFLKLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10973.61 Da        Isoelectric Point: 4.5625

>AT277464 WP_072141942.1 NZ_CP122638:10952-11236 [Escherichia coli]
MIYGGFMKSDVQLNLRARESQRILIDTAAEILHKSRTDFILEMACKAAEDVILDRRVFNFNDRQYEEFIEMLDAPVADEP
AIEKLLARKPQWDV

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L6ZF90

Antitoxin

Source ID Structure

References