Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3968535..3969153 Replicon chromosome
Accession NZ_CP122634
Organism Escherichia coli strain ETEC4085

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDW62_RS19995 Protein ID WP_001291435.1
Coordinates 3968935..3969153 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDW62_RS19990 Protein ID WP_000344800.1
Coordinates 3968535..3968909 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW62_RS19980 (3963624) 3963624..3964817 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDW62_RS19985 (3964840) 3964840..3967989 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QDW62_RS19990 (3968535) 3968535..3968909 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDW62_RS19995 (3968935) 3968935..3969153 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDW62_RS20000 (3969325) 3969325..3969876 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDW62_RS20005 (3969992) 3969992..3970462 + 471 WP_000136192.1 YlaC family protein -
QDW62_RS20010 (3970626) 3970626..3972176 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDW62_RS20015 (3972218) 3972218..3972571 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDW62_RS20025 (3972950) 3972950..3973261 + 312 WP_000409911.1 MGMT family protein -
QDW62_RS20030 (3973292) 3973292..3973864 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277455 WP_001291435.1 NZ_CP122634:3968935-3969153 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277455 WP_000344800.1 NZ_CP122634:3968535-3968909 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References