277451

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2546328..2546854 Replicon chromosome
Accession NZ_CP122634
Organism Escherichia coli strain ETEC4085

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag QDW62_RS12745 Protein ID WP_000323025.1
Coordinates 2546567..2546854 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag QDW62_RS12740 Protein ID WP_000534858.1
Coordinates 2546328..2546567 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW62_RS12715 (2541526) 2541526..2542713 + 1188 WP_000937614.1 IS91-like element IS91 family transposase -
QDW62_RS12720 (2543734) 2543734..2544756 + 1023 Protein_2485 ISNCY family transposase -
QDW62_RS12725 (2544877) 2544877..2545026 + 150 WP_011443592.1 protein YdfW -
QDW62_RS12730 (2545463) 2545463..2545795 - 333 WP_001301033.1 FlxA-like family protein -
QDW62_RS12735 (2545998) 2545998..2546303 - 306 WP_001326990.1 protein YdfV -
QDW62_RS12740 (2546328) 2546328..2546567 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
QDW62_RS12745 (2546567) 2546567..2546854 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
QDW62_RS12750 (2546926) 2546926..2547081 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
QDW62_RS12755 (2547298) 2547298..2547549 + 252 WP_000980994.1 protein Rem -
QDW62_RS12760 (2547616) 2547616..2547894 + 279 WP_012304870.1 hypothetical protein -
QDW62_RS12765 (2547896) 2547896..2548945 + 1050 WP_001424248.1 DUF968 domain-containing protein -
QDW62_RS12770 (2548959) 2548959..2549711 + 753 WP_001047136.1 antitermination protein -
QDW62_RS12775 (2549989) 2549989..2550078 - 90 WP_120795389.1 hypothetical protein -
QDW62_RS12780 (2550133) 2550133..2550345 - 213 WP_000087756.1 cold shock-like protein CspF -
QDW62_RS12785 (2550646) 2550646..2550861 + 216 WP_000066484.1 cold shock-like protein CspB -
QDW62_RS12790 (2551225) 2551225..2551395 - 171 WP_001405948.1 putative zinc-binding protein YnfU -
QDW62_RS12795 (2551615) 2551615..2551830 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2519636..2589244 69608
- flank IS/Tn - - 2541526..2542713 1187
- inside Prophage - - 2527355..2589244 61889


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T277451 WP_000323025.1 NZ_CP122634:2546567-2546854 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT277451 WP_000534858.1 NZ_CP122634:2546328-2546567 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References